Use of Pressure-volume Conductance Catheters in Real-time Cardiovascular Experimentation
Author(s)Wei, Abraham E.; Maslov, Mikhail Y.; Pezone, Matthew J.; Lovich, Mark A.; Edelman, Elazer R
MetadataShow full item record
Background: Most applications of pressure-volume conductance catheter measurements assess cardiovascular function at a single point in time after genetic, pharmacologic, infectious, nutritional, or toxicologic manipulation. Use of these catheters as a continuous monitor, however, is fraught with complexities and limitations. Methods: Examples of the limitations and optimal use of conductance catheters as a continuous, real-time monitor of cardiovascular function are demonstrated during inotropic drug infusion in anesthetised rats. Results: Inotropic drug infusion may alter ventricular dimensions causing relative movement of a well-positioned catheter, generating artifacts, including an abrupt pressure rise at end-systole that leads to over estimation of indices of contractility (max dP/dt) and loss of stroke volume signal. Simple rotation of the catheter, echocardiography-guided placement to the centre of the ventricle, or ventricular expansion through crystalloid infusion may correct for these artifacts. Fluid administration, however, alters left ventricular end-diastolic pressure and volume and therefore stroke volume, thereby obscuring continuous real-time haemodynamic measurements. Conclusions: Pressure-volume artifacts during inotropic infusion are caused by physical contact of the catheter with endocardium. Repeated correction of catheter position may be required to use pressure volume catheters as a continuous real-time monitor during manipulations that alter ventricular dimensions, such as inotropic therapy.
DepartmentHarvard University--MIT Division of Health Sciences and Technology
Heart, Lung and Circulation
Wei, Abraham E. et al. “Use of Pressure-Volume Conductance Catheters in Real-Time Cardiovascular Experimentation.” Heart, Lung and Circulation 23.11 (2014): 1059–1069.
Author's final manuscript