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Inferring transient particle transport dynamics in live cells

dc.contributor.authorPark, Hye Yoon
dc.contributor.authorKatz, Zachary
dc.contributor.authorEnglish, Brian P.
dc.contributor.authorSinger, Robert H.
dc.contributor.authorMonnier, Nilah
dc.contributor.authorBarry, Zachary Thomas
dc.contributor.authorSu, Kuan-Chung
dc.contributor.authorDey, Arkajit
dc.contributor.authorPan, Keyao
dc.contributor.authorCheeseman, Iain M
dc.contributor.authorBathe, Mark
dc.date.accessioned2017-01-17T19:12:46Z
dc.date.available2017-01-17T19:12:46Z
dc.date.issued2015-07
dc.date.submitted2015-01
dc.identifier.issn1548-7091
dc.identifier.issn1548-7105
dc.identifier.urihttp://hdl.handle.net/1721.1/106511
dc.description.abstractLive-cell imaging and particle tracking provide rich information on mechanisms of intracellular transport. However, trajectory analysis procedures to infer complex transport dynamics involving stochastic switching between active transport and diffusive motion are lacking. We applied Bayesian model selection to hidden Markov modeling to infer transient transport states from trajectories of mRNA-protein complexes in live mouse hippocampal neurons and metaphase kinetochores in dividing human cells. The software is available at http://hmm-bayes.org/.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.)en_US
dc.description.sponsorshipNational Institute of Mental Health (U.S.) (Grant U01 MH106011)en_US
dc.description.sponsorshipNational Science Foundation (U.S.). Physics of Living Systems (Grant PHY 1305537)en_US
dc.description.sponsorshipLeukemia & Lymphoma Society of America (Scholar Award)en_US
dc.description.sponsorshipNational Institute of General Medical Sciences (U.S.) (Grant GM088313)en_US
dc.description.sponsorshipAustrian Science Fund (Schroedinger Fellowship)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/nmeth.3483en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleInferring transient particle transport dynamics in live cellsen_US
dc.typeArticleen_US
dc.identifier.citationMonnier, Nilah et al. “Inferring Transient Particle Transport Dynamics in Live Cells.” Nature Methods 12.9 (2015): 838–840.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorMonnier, Nilah
dc.contributor.mitauthorBarry, Zachary Thomas
dc.contributor.mitauthorSu, Kuan-Chung
dc.contributor.mitauthorDey, Arkajit
dc.contributor.mitauthorPan, Keyao
dc.contributor.mitauthorCheeseman, Iain M
dc.contributor.mitauthorBathe, Mark
dc.relation.journalNature Methodsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsMonnier, Nilah; Barry, Zachary; Park, Hye Yoon; Su, Kuan-Chung; Katz, Zachary; English, Brian P; Dey, Arkajit; Pan, Keyao; Cheeseman, Iain M; Singer, Robert H; Bathe, Marken_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-8844-7170
dc.identifier.orcidhttps://orcid.org/0000-0003-4573-5206
dc.identifier.orcidhttps://orcid.org/0000-0002-3829-5612
dc.identifier.orcidhttps://orcid.org/0000-0002-6199-6855
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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