Tools for the Microbiome: Nano and Beyond
Author(s)Biteen, Julie S.; Cardon, Zoe G.; Chun, Miyoung; Church, George M.; Dorrestein, Pieter C.; Fraser, Scott E.; Gilbert, Jack A.; Jansson, Janet K.; Knight, Rob; Miller, Jeff F.; Ozcan, Aydogan; Prather, Kimberly A.; Quake, Stephen R.; Ruby, Edward G.; Silver, Pamela A.; Taha, Sharif; van den Engh, Ger; Weiss, Paul S.; Wong, Gerard C. L.; Wright, Aaron T.; Young, Thomas D.; Blainey, Paul C; ... Show more Show less
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The microbiome presents great opportunities for understanding and improving the world around us and elucidating the interactions that compose it. The microbiome also poses tremendous challenges for mapping and manipulating the entangled networks of interactions among myriad diverse organisms. Here, we describe the opportunities, technical needs, and potential approaches to address these challenges, based on recent and upcoming advances in measurement and control at the nanoscale and beyond. These technical needs will provide the basis for advancing the largely descriptive studies of the microbiome to the theoretical and mechanistic understandings that will underpin the discipline of microbiome engineering. We anticipate that the new tools and methods developed will also be more broadly useful in environmental monitoring, medicine, forensics, and other areas.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering
American Chemical Society (ACS)
Biteen, Julie S., Paul C. Blainey, Zoe G. Cardon, et al. “Tools for the Microbiome: Nano and Beyond.” ACS Nano, vol. 10, no. 1, 2016, pp. 6–37. © 2015 American Chemical Society.
Final published version