B Cells Promote Pancreatic Tumorigenesis
Author(s)Roghanian, Ali; Fraser, Christopher; Kleyman, Marianna; Chen, Jianzhu
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Summary: Three recent studies, approaching the question from different angles and using different and/or overlapping models, provide compelling evidence for the involvement of tumor-infiltrating B cells in the initiation and progression of pancreatic ductal adenocarcinoma. These studies highlight the need for a better understanding of pancreatic tumor–immune system interactions and the immunologic mechanisms that promote or inhibit tumorigenesis, paving the way for better treatment strategies.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biology
American Association for Cancer Research (AACR)
Roghanian, Ali, Christopher Fraser, Marianna Kleyman, and Jianzhu Chen. “B Cells Promote Pancreatic Tumorigenesis.” Cancer Discovery 6, no. 3 (March 1, 2016): 230-232.
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