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Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport

dc.contributor.authorKim, Minkyu
dc.contributor.authorChen, Wesley George
dc.contributor.authorRibbeck, Katharina
dc.contributor.authorOlsen, Bradley D
dc.contributor.authorKang, Jeon Woong
dc.contributor.authorGlassman, Matthew J.
dc.date.accessioned2017-02-02T20:31:19Z
dc.date.available2017-02-02T20:31:19Z
dc.date.issued2015-06
dc.date.submitted2015-04
dc.identifier.issn0935-9648
dc.identifier.issn1521-4095
dc.identifier.urihttp://hdl.handle.net/1721.1/106834
dc.description.abstractNucleoporin-like polypeptide (NLP) hydrogels are developed by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo–carrier complexes similar to the natural nuclear pore system. The engineered protein gels additionally have tunable mechanical and transport properties and can be biosynthesized at high yield, making them promising materials for advanced separation technologies.en_US
dc.description.sponsorshipUnited States. Defense Threat Reduction Agency (Grant HDTRA1-13-1-0038)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant 5-T32-GM008834)en_US
dc.description.sponsorshipNational Institute for Biomedical Imaging and Bioengineering (U.S.) (Grant P41EB015871-28)en_US
dc.description.sponsorshipMIT Skoltech Initiativeen_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/adma.201500752en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleArtificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transporten_US
dc.typeArticleen_US
dc.identifier.citationKim, Minkyu et al. “Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport.” Advanced Materials 27.28 (2015): 4207–4212.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Laser Biomedical Research Centeren_US
dc.contributor.mitauthorKim, Minkyu
dc.contributor.mitauthorChen, Wesley George
dc.contributor.mitauthorGlassman, Matthew James
dc.contributor.mitauthorRibbeck, Katharina
dc.contributor.mitauthorOlsen, Bradley D
dc.contributor.mitauthorKang, Jeon Woong
dc.relation.journalAdvanced Materialsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsKim, Minkyu; Chen, Wesley G.; Kang, Jeon Woong; Glassman, Matthew J.; Ribbeck, Katharina; Olsen, Bradley D.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-9476-6351
dc.identifier.orcidhttps://orcid.org/0000-0003-1646-2456
dc.identifier.orcidhttps://orcid.org/0000-0001-8260-338X
dc.identifier.orcidhttps://orcid.org/0000-0002-7272-7140
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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