Heritability in the genome-wide association era
Author(s)
Zaitlen, Noah; Kraft, Peter
Download439_2012_Article_1199.pdf (346.7Kb)
PUBLISHER_POLICY
Publisher Policy
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Terms of use
Metadata
Show full item recordAbstract
Heritability, the fraction of phenotypic variation explained by genetic variation, has been estimated for many phenotypes in a range of populations, organisms, and time points. The recent development of efficient genotyping and sequencing technology has led researchers to attempt to identify the genetic variants responsible for the genetic component of phenotype directly via GWAS. The gap between the phenotypic variance explained by GWAS results and those estimated from classical heritability methods has been termed the “missing heritability problem”. In this work, we examine modern methods for estimating heritability, which use the genotype and sequence data directly. We discuss them in the context of classical heritability methods, the missing heritability problem, and describe their implications for understanding the genetic architecture of complex phenotypes.
Date issued
2012-07Department
Broad Institute of MIT and HarvardJournal
Human Genetics
Publisher
Springer-Verlag
Citation
Zaitlen, Noah, and Peter Kraft. “Heritability in the Genome-Wide Association Era.” Human Genetics 131.10 (2012): 1655–1664.
Version: Author's final manuscript
ISSN
0340-6717
1432-1203