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Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery

dc.contributor.authorDeRosa, Frank
dc.contributor.authorLanger, Robert
dc.contributor.authorKauffman, Kevin John
dc.contributor.authorMcClellan, Rebecca L
dc.contributor.authorAppel, Eric
dc.contributor.authorDorkin, Joseph Robert
dc.contributor.authorTibbitt, Mark W
dc.contributor.authorLanger, Robert S
dc.contributor.authorAnderson, Daniel Griffith
dc.contributor.authorFenton, Owen Shea
dc.date.accessioned2017-02-10T15:50:07Z
dc.date.available2017-02-10T15:50:07Z
dc.date.issued2016-02
dc.date.submitted2016-01
dc.identifier.issn0935-9648
dc.identifier.issn1521-4095
dc.identifier.urihttp://hdl.handle.net/1721.1/106890
dc.description.abstractThousands of human diseases could be treated by selectively controlling the expression of specific proteins in vivo. A new series of alkenyl amino alcohol (AAA) ionizable lipid nanoparticles (LNPs) capable of delivering human mRNA with unprecedented levels of in vivo efficacy is demonstrated. This study highlights the importance of utilizing synthesis tools in tandem with biological inspiration to understand and improve nucleic acid delivery in vivo.en_US
dc.description.sponsorshipNational Science Foundation (U.S.). Graduate Research Fellowship Programen_US
dc.description.sponsorshipShire Pharmaceuticalsen_US
dc.description.sponsorshipWellcome Trust-MIT Postdoctoral Fellowshipen_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/adma.201505822en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleBioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Deliveryen_US
dc.typeArticleen_US
dc.identifier.citationFenton, Owen S. et al. “Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery.” Advanced Materials 28.15 (2016): 2939–2943.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorFenton, Owen S.
dc.contributor.mitauthorKauffman, Kevin John
dc.contributor.mitauthorMcClellan, Rebecca L
dc.contributor.mitauthorAppel, Eric
dc.contributor.mitauthorDorkin, Joseph Robert
dc.contributor.mitauthorTibbitt, Mark W
dc.contributor.mitauthorLanger, Robert S
dc.contributor.mitauthorAnderson, Daniel Griffith
dc.relation.journalAdvanced Materialsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsFenton, Owen S.; Kauffman, Kevin J.; McClellan, Rebecca L.; Appel, Eric A.; Dorkin, J. Robert; Tibbitt, Mark W.; Heartlein, Michael W.; DeRosa, Frank; Langer, Robert; Anderson, Daniel G.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-5585-9280
dc.identifier.orcidhttps://orcid.org/0000-0002-9436-2453
dc.identifier.orcidhttps://orcid.org/0000-0002-2301-7126
dc.identifier.orcidhttps://orcid.org/0000-0002-4917-7187
dc.identifier.orcidhttps://orcid.org/0000-0003-4255-0492
dc.identifier.orcidhttps://orcid.org/0000-0001-5629-4798
mit.licenseOPEN_ACCESS_POLICYen_US


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