The importance of serine metabolism in cancer
Author(s)Mattaini, Katherine Ruth; Sullivan, Mark Robert; Vander Heiden, Matthew G.
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Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells increase serine synthesis from glucose and require de novo serine synthesis even in the presence of abundant extracellular serine. Recent studies cast new light on the role of serine metabolism in cancer, suggesting that active serine synthesis might be required to facilitate amino acid transport, nucleotide synthesis, folate metabolism, and redox homeostasis in a manner that impacts cancer.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biology
Journal of Cell Biology
Rockefeller University Press
Mattaini, Katherine R., Mark R. Sullivan, and Matthew G. Vander Heiden. “The Importance of Serine Metabolism in Cancer.” The Journal of Cell Biology 214, no. 3 (July 25, 2016): 249–257.
Final published version