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The importance of serine metabolism in cancer

Author(s)
Mattaini, Katherine Ruth; Sullivan, Mark Robert; Vander Heiden, Matthew G.
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Abstract
Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells increase serine synthesis from glucose and require de novo serine synthesis even in the presence of abundant extracellular serine. Recent studies cast new light on the role of serine metabolism in cancer, suggesting that active serine synthesis might be required to facilitate amino acid transport, nucleotide synthesis, folate metabolism, and redox homeostasis in a manner that impacts cancer.
Date issued
2016-07
URI
http://hdl.handle.net/1721.1/107134
Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Journal
Journal of Cell Biology
Publisher
Rockefeller University Press
Citation
Mattaini, Katherine R., Mark R. Sullivan, and Matthew G. Vander Heiden. “The Importance of Serine Metabolism in Cancer.” The Journal of Cell Biology 214, no. 3 (July 25, 2016): 249–257.
Version: Final published version
ISSN
0021-9525
1540-8140

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