dc.contributor.author | Large, E. M. | |
dc.contributor.author | Hughes, D. J. | |
dc.contributor.author | Stokes, C. L. | |
dc.contributor.author | Yu, Jiajie | |
dc.contributor.author | Cilfone, Nicholas A. | |
dc.contributor.author | Sarkar, Ujjal | |
dc.contributor.author | Tannenbaum, Steven R | |
dc.contributor.author | Lauffenburger, Douglas A | |
dc.contributor.author | Griffith, Linda G | |
dc.contributor.author | Cirit, Murat | |
dc.contributor.author | Wishnok, John S. | |
dc.date.accessioned | 2017-03-02T20:59:46Z | |
dc.date.available | 2017-03-02T20:59:46Z | |
dc.date.issued | 2015-10 | |
dc.identifier.issn | 2163-8306 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/107165 | |
dc.description.abstract | Our goal in developing Microphysiological Systems (MPS) technology is to provide an improved approach for more predictive preclinical drug discovery via a highly integrated experimental/computational paradigm. Success will require quantitative characterization of MPSs and mechanistic analysis of experimental findings sufficient to translate resulting insights from in vitro to in vivo. We describe herein a systems pharmacology approach to MPS development and utilization that incorporates more mechanistic detail than traditional pharmacokinetic/pharmacodynamic (PK/PD) models. A series of studies illustrates diverse facets of our approach. First, we demonstrate two case studies: a PK data analysis and an inflammation response––focused on a single MPS, the liver/immune MPS. Building on the single MPS modeling, a theoretical investigation of a four-MPS interactome then provides a quantitative way to consider several pharmacological concepts such as absorption, distribution, metabolism, and excretion in the design of multi-MPS interactome operation and experiments. | en_US |
dc.description.sponsorship | United States. Defense Advanced Research Projects Agency. Microphysiological Systems Program (W911NF-12-2-0039) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) Microphysiological Systems Program (4-UH3-TR000496-03) | en_US |
dc.description.sponsorship | Massachusetts Institute of Technology. Center for Environmental Health Sciences (NIEHS Grant P30-ES002109) | en_US |
dc.language.iso | en_US | |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1002/psp4.12010 | en_US |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.source | Nature | en_US |
dc.title | Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Yu, J, NA Cilfone, EM Large, U Sarkar, JS Wishnok, SR Tannenbaum, DJ Hughes, et al. “Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration.” CPT: Pharmacometrics & Systems Pharmacology 4, no. 10 (October 2015): 585–594. © 2017 American Society for Clinical Pharmacology and Therapeutics | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Center for Gynepathology Research | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.department | Massachusetts Institute of Technology. School of Engineering | en_US |
dc.contributor.mitauthor | Yu, Jiajie | |
dc.contributor.mitauthor | Cilfone, Nicholas A. | |
dc.contributor.mitauthor | Sarkar, Ujjal | |
dc.contributor.mitauthor | Wishnok, John S | |
dc.contributor.mitauthor | Tannenbaum, Steven R | |
dc.contributor.mitauthor | Lauffenburger, Douglas A | |
dc.contributor.mitauthor | Griffith, Linda G | |
dc.contributor.mitauthor | Cirit, Murat | |
dc.relation.journal | CPT: Pharmacometrics & Systems Pharmacology | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Yu, J; Cilfone, NA; Large, EM; Sarkar, U; Wishnok, JS; Tannenbaum, SR; Hughes, DJ; Lauffenburger, DA; Griffith, LG; Stokes, CL; Cirit, M | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-6975-5047 | |
dc.identifier.orcid | https://orcid.org/0000-0002-2325-552X | |
dc.identifier.orcid | https://orcid.org/0000-0002-1801-5548 | |
mit.license | PUBLISHER_CC | en_US |