High throughput screening for discovery of materials that control stem cell fate
Author(s)Celiz, Adam D.; Davies, Martyn C.; Denning, Chris; Alexander, Morgan R.; Tibbitt, Mark W; Langer, Robert S; Anderson, Daniel Griffith; Patel, Asha; ... Show more Show less
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Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit specific cellular responses. To accelerate materials discovery, high throughput screening platforms have been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional environments. In this review, we present screening platforms for the discovery of material properties that influence stem cell behavior.
DepartmentHarvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
Current Opinion in Solid State and Materials Science
Patel, Asha K. et al. “High Throughput Screening for Discovery of Materials That Control Stem Cell Fate.” Current Opinion in Solid State and Materials Science 20.4 (2016): 202–211.
Final published version