Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits
Author(s)
Aguirre-Gamboa, Raul; Joosten, Irma; Urbano, Paulo C.M.; van der Molen, Renate G.; van Rijssen, Esther; van Cranenbroek, Bram; Oosting, Marije; Smeekens, Sanne; Jaeger, Martin; Zorro, Maria; Withoff, Sebo; van Herwaarden, Antonius E.; Sweep, Fred C.G.J.; Netea, Romana T.; Swertz, Morris A.; Franke, Lude; Joosten, Leo A.B.; Netea, Mihai G.; Wijmenga, Cisca; Kumar, Vinod; Li, Yang; Koenen, Hans J.P.M.; Xavier, Ramnik Joseph; ... Show more Show less
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Effective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors. We used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell populations in peripheral blood, including associations with immunoglobulin concentrations, from ∼500 healthy volunteers from the Human Functional Genomics Project. Genetic heritability estimation showed that variations in T cell numbers are more strongly driven by genetic factors, while B cell counts are more environmentally influenced. Quantitative trait loci (QTL) mapping identified eight independent genomic loci associated with leukocyte count variation, including four associations with T and B cell subtypes. The QTLs identified were enriched among genome-wide association study (GWAS) SNPs reported to increase susceptibility to immune-mediated diseases. Our systems approach provides insights into cellular and humoral immune trait variability in humans.
Date issued
2016-11Department
Institute for Medical Engineering and ScienceJournal
Cell Reports
Publisher
Elsevier
Citation
Aguirre-Gamboa, Raul et al. “Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits.” Cell Reports 17.9 (2016): 2474–2487.
Version: Final published version
ISSN
2211-1247