Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins
Author(s)Zhu, Xi; Wu, Jun; Shan, Wei; Tao, Wei; Zhao, Lili; Lim, Jong-Min; D'Ortenzio, Mathew; Karnik, Rohit; Huang, Yuan; Shi, Jinjun; Farokhzad, Omid C.; ... Show more Show less
MetadataShow full item record
Effective delivery of therapeutic proteins is a formidable challenge. Herein, using a unique polymer family with a wide-ranging set of cationic and hydrophobic features, we developed a novel nanoparticle (NP) platform capable of installing protein ligands on the particle surface and simultaneously carrying therapeutic proteins inside by a self-assembly procedure. The loaded therapeutic proteins (e.g., insulin) within the NPs exhibited sustained and tunable release, while the surface-coated protein ligands (e.g., transferrin) were demonstrated to alter the NP cellular behaviors. In vivo results revealed that the transferrin-coated NPs can effectively be transported across the intestinal epithelium for oral insulin delivery, leading to a notable hypoglycemic response.
DepartmentMassachusetts Institute of Technology. Department of Mechanical Engineering
Angewandte Chemie International Edition
Zhu, Xi et al. “Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins.” Angewandte Chemie International Edition 55.10 (2016): 3309–3312.
Author's final manuscript