MIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Genetic characterization of H5N2 influenza viruses isolated from wild birds in Japan suggests multiple reassortment

Author(s)
Sultan, Serageldeen; Inage, Kumiko; Hashizume, Taishi; Ogawa, Haruko; Imai, Kunitoshi; Bui, Vuong Nghia; Trinh, Dai Quang; Hill, Nichola; Hussein, Islam; Runstadler, Jonathan; ... Show more Show less
Thumbnail
Download705_2016_Article_3023.pdf (2.989Mb)
OPEN_ACCESS_POLICY

Open Access Policy

Creative Commons Attribution-Noncommercial-Share Alike

Terms of use
Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/
Metadata
Show full item record
Abstract
Low-pathogenic avian influenza viruses (LPAIVs) of the H5 subtype can mutate to highly pathogenic forms, potentially destabilizing the poultry industry. Wild migratory birds are considered a natural reservoir of LPAIVs capable of dispersing both high- and low-pathogenic forms of the virus. Therefore, surveillance and characterization of AIV in wild birds are essential. Here, we report on the isolation and genetic characterization of 10 AIVs of the H5N2 subtype obtained through surveillance in Hokkaido, Japan, during 2009 and 2011. Full-genome sequencing revealed that the H5 and N2 genes of these isolates are all closely related to each other, belonging to the Eurasian avian-like lineage, but they are unrelated to H5 highly pathogenic strains of clade 2.3.4.4. The internal genes of the isolates were found to be diverse, consistent with our hypothesis that these H5N2 strains have undergone multiple reassortment events. Even though all of the H5N2 isolates were characterized as LPAIV based on the amino acid sequences at the HA cleavage site, this analysis demonstrates a diverse pool of precursors that may seed future outbreaks in poultry and possible human transmissions, suggesting the need for high-quality surveillance.
Date issued
2016-08
URI
http://hdl.handle.net/1721.1/107259
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Division of Comparative Medicine
Journal
Archives of Virology
Publisher
Springer Vienna
Citation
Sultan, Serageldeen, Vuong Nghia Bui, Nichola J. Hill, Islam T. M. Hussein, Dai Quang Trinh, Kumiko Inage, Taishi Hashizume, Jonathan A. Runstadler, Haruko Ogawa, and Kunitoshi Imai. “Genetic Characterization of H5N2 Influenza Viruses Isolated from Wild Birds in Japan Suggests Multiple Reassortment.” Archives of Virology 161, no. 12 (August 30, 2016): 3309–3322.
Version: Author's final manuscript
ISSN
0304-8608
1432-8798

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries
PrivacyPermissionsAccessibilityContact us
MIT
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.