Synthesis of colloidal microgels using oxygen-controlled flow lithography
Author(s)An, Harry; Eral, Huseyin Burak; Chen, Lynna; Chen, Michelle B; Doyle, Patrick S
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We report a synthesis approach based on stop-flow lithography (SFL) for fabricating colloidal microparticles with any arbitrary 2D-extruded shape. By modulating the degree of oxygen inhibition during synthesis, we achieved previously unattainable particle sizes. Brownian diffusion of colloidal discs in bulk suggests the out-of-plane dimension can be as small as 0.8 μm, which agrees with confocal microscopy measurements. We measured the hindered diffusion of microdiscs near a solid surface and compared our results to theoretical predictions. These colloidal particles can also flow through physiological microvascular networks formed by endothelial cells undergoing vasculogensis under minimal hydrostatic pressure (∼5 mm H2O). This versatile platform creates future opportunities for on-chip parametric studies of particle geometry effects on particle passage properties, distribution and cellular interactions.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering
Royal Society of Chemistry
An, Harry Z. et al. “Synthesis of Colloidal Microgels Using Oxygen-Controlled Flow Lithography.” Soft Matter 10.38 (2014): 7595–7605.
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