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dc.contributor.authorDang, Xiangnan
dc.contributor.authorGu, Li
dc.contributor.authorQi, Jifa
dc.contributor.authorCorrea Echavarria, Santiago
dc.contributor.authorZhang, Geran
dc.contributor.authorBelcher, Angela M
dc.contributor.authorHammond, Paula T
dc.date.accessioned2017-03-28T20:31:23Z
dc.date.available2017-03-28T20:31:23Z
dc.date.issued2016-05
dc.date.submitted2015-10
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1721.1/107760
dc.description.abstractFluorescence imaging in the second near-infrared window (NIR-II, 1,000–1,700 nm) features deep tissue penetration, reduced tissue scattering, and diminishing tissue autofluorescence. Here, NIR-II fluorescent probes, including down-conversion nanoparticles, quantum dots, single-walled carbon nanotubes, and organic dyes, are constructed into biocompatible nanoparticles using the layer-by-layer (LbL) platform due to its modular and versatile nature. The LbL platform has previously been demonstrated to enable incorporation of diagnostic agents, drugs, and nucleic acids such as siRNA while providing enhanced blood plasma half-life and tumor targeting. This work carries out head-to-head comparisons of currently available NIR-II probes with identical LbL coatings with regard to their biodistribution, pharmacokinetics, and toxicities. Overall, rare-earth-based down-conversion nanoparticles demonstrate optimal biological and optical performance and are evaluated as a diagnostic probe for high-grade serous ovarian cancer, typically diagnosed at late stage. Successful detection of orthotopic ovarian tumors is achieved by in vivo NIR-II imaging and confirmed by ex vivo microscopic imaging. Collectively, these results indicate that LbL-based NIR-II probes can serve as a promising theranostic platform to effectively and noninvasively monitor the progression and treatment of serous ovarian cancer.en_US
dc.description.sponsorshipUnited States. Department of Defense. Ovarian Cancer Research Program (TEAL Innovator Award OC120504)en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (Center for Cancer Nanotechnology Excellence Grant 5-U54- CA151884-03)en_US
dc.language.isoen_US
dc.publisherNational Academy of Sciences (U.S.)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.1521175113en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePNASen_US
dc.titleLayer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian canceren_US
dc.typeArticleen_US
dc.identifier.citationDang, Xiangnan et al. “Layer-by-Layer Assembled Fluorescent Probes in the Second near-Infrared Window for Systemic Delivery and Detection of Ovarian Cancer.” Proceedings of the National Academy of Sciences 113.19 (2016): 5179–5184. © 2016 National Academy of Sciencesen_US
dc.contributor.departmentDavid H. Koch Institute for Integrative Cancer Research at MITen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Materials Science and Engineeringen_US
dc.contributor.mitauthorDang, Xiangnan
dc.contributor.mitauthorGu, Li
dc.contributor.mitauthorQi, Jifa
dc.contributor.mitauthorCorrea Echavarria, Santiago
dc.contributor.mitauthorZhang, Geran
dc.contributor.mitauthorBelcher, Angela M
dc.contributor.mitauthorHammond, Paula T
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsDang, Xiangnan; Gu, Li; Qi, Jifa; Correa, Santiago; Zhang, Geran; Belcher, Angela M.; Hammond, Paula T.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7530-4725
dc.identifier.orcidhttps://orcid.org/0000-0001-8230-4945
dc.identifier.orcidhttps://orcid.org/0000-0002-0378-351X
dc.identifier.orcidhttps://orcid.org/0000-0001-9353-7453
mit.licensePUBLISHER_POLICYen_US


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