Show simple item record

dc.contributor.authorBhatla, Nikhil
dc.contributor.authorHorvitz, Howard Robert
dc.date.accessioned2017-04-05T15:03:54Z
dc.date.available2017-04-05T15:03:54Z
dc.date.issued2015-01
dc.date.submitted2014-11
dc.identifier.issn0896-6273
dc.identifier.issn1097-4199
dc.identifier.urihttp://hdl.handle.net/1721.1/107846
dc.description.abstractWhile gustatory sensing of the five primary flavors (sweet, salty, sour, bitter, and savory) has been extensively studied, pathways that detect non-canonical taste stimuli remain relatively unexplored. In particular, while reactive oxygen species cause generalized damage to biological systems, no gustatory mechanism to prevent ingestion of such material has been identified in any organism. We observed that light inhibits C. elegans feeding and used light as a tool to uncover molecular and neural mechanisms for gustation. Light can generate hydrogen peroxide, and we discovered that hydrogen peroxide similarly inhibits feeding. The gustatory receptor family members LITE-1 and GUR-3 are required for the inhibition of feeding by light and hydrogen peroxide. The I2 pharyngeal neurons increase calcium in response to light and hydrogen peroxide, and these responses require GUR-3 and a conserved antioxidant enzyme peroxiredoxin PRDX-2. Our results demonstrate a gustatory mechanism that mediates the detection and blocks ingestion of a noncanonical taste stimulus, hydrogen peroxide.en_US
dc.description.sponsorshipNational Science Foundation (U.S.). Graduate Research Fellowship Programen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant GM24663)en_US
dc.language.isoen_US
dc.publisherElsevier/Cell Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.neuron.2014.12.061en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleLight and Hydrogen Peroxide Inhibit C. elegans Feeding through Gustatory Receptor Orthologs and Pharyngeal Neuronsen_US
dc.typeArticleen_US
dc.identifier.citationBhatla, Nikhil, and H. Robert Horvitz. “Light and Hydrogen Peroxide Inhibit C. Elegans Feeding through Gustatory Receptor Orthologs and Pharyngeal Neurons.” Neuron 85.4 (2015): 804–818.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.mitauthorBhatla, Nikhil
dc.contributor.mitauthorHorvitz, Howard Robert
dc.relation.journalNeuronen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsBhatla, Nikhil; Horvitz, H. Roberten_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-1693-4524
dc.identifier.orcidhttps://orcid.org/0000-0002-9964-9613
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record