Building Robust Transcriptomes with Master Splicing Factors

Author(s)
Sharp, Phillip A.; Jangi, Mohini Rohit
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Abstract
Coherent splicing networks arise from many discrete splicing decisions regulated in unison. Here, we examine the properties of robust, context-specific splicing networks. We propose that a subset of key splicing regulators, or “master splicing factors,” respond to environmental cues to establish and maintain tissue transcriptomes during development.
Date issued
2014-10
URI
http://hdl.handle.net/1721.1/107944
Department
Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Journal
Cell
Publisher
Elsevier
Citation
Jangi, Mohini, and Phillip A. Sharp. “Building Robust Transcriptomes with Master Splicing Factors.” Cell 159, no. 3 (October 2014): 487–498. © 2014 Elsevier Inc.
Version: Author's final manuscript
ISSN
00928674
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