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dc.contributor.authorMcFetridge, Kiva
dc.contributor.authorCamejo, Ana
dc.contributor.authorGold, Daniel A.
dc.contributor.authorLu, Diana
dc.contributor.authorJulien, Lindsay
dc.contributor.authorYang, Ninghan
dc.contributor.authorJensen, Kirk D C
dc.contributor.authorSaeij, Jeroen
dc.date.accessioned2017-04-20T20:12:43Z
dc.date.available2017-04-20T20:12:43Z
dc.date.issued2013-09
dc.date.submitted2013-08
dc.identifier.issn0020-7519
dc.identifier.urihttp://hdl.handle.net/1721.1/108319
dc.description.abstractThe rhoptries are key secretory organelles from apicomplexan parasites that contain proteins involved in invasion and modulation of the host cell. Some rhoptry proteins are restricted to the posterior bulb (ROPs) and others to the anterior neck (RONs). As many rhoptry proteins have been shown to be key players in Toxoplasma invasion and virulence, it is important to identify, understand and characterise the biological function of the components of the rhoptries. In this report, we identified putative novel rhoptry genes by identifying Toxoplasma genes with similar cyclical expression profiles as known rhoptry protein encoding genes. Using this approach we identified two new rhoptry bulb (ROP47 and ROP48) and one new rhoptry neck protein (RON12). ROP47 is secreted and traffics to the host cell nucleus, RON12 was not detected at the moving junction during invasion. Deletion of ROP47 or ROP48 in a type II strain did not show major influence in in vitro growth or virulence in mice.en_US
dc.description.sponsorshipUnited States. National Institutes of Health (R01-AI080621)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.ijpara.2013.08.002en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourceAna Camejoen_US
dc.titleIdentification of three novel Toxoplasma gondii rhoptry proteinsen_US
dc.typeArticleen_US
dc.identifier.citationCamejoa, Ana; Golda, Daniel A.; Lua, Diana; McFetridge, Kiva et al. "Identification of three novel Toxoplasma gondii rhoptry proteins." International Journal for Parasitology 44, no. 2 (February 2014):147–160. © 2013 Australian Society for Parasitology Incen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.approverSaeij, Jeroenen_US
dc.contributor.mitauthorCamejo, Ana
dc.contributor.mitauthorGold, Daniel A.
dc.contributor.mitauthorLu, Diana
dc.contributor.mitauthorJulien, Lindsay
dc.contributor.mitauthorYang, Ninghan
dc.contributor.mitauthorJensen, Kirk D C
dc.contributor.mitauthorSaeij, Jeroen
dc.relation.journalInternational Journal for Parasitologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsCamejoa, Ana; Golda, Daniel A.; Lua, Diana; McFetridge, Kiva; Juliena, Lindsay; Yanga, Ninghan; Jensen, Kirk D.C.; Saeija, Jeroen P.J.en_US
dspace.embargo.termsNen_US
mit.licensePUBLISHER_CCen_US


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