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A polyalanine peptide derived from polar fish with anti-infectious activities

Author(s)
Cardoso, Marlon H.; Ribeiro, Suzana M.; Felício, Mário R.; Gonçalves, Sónia; Matos, Carolina O.; Liao, Luciano M.; Santos, Nuno C.; Hancock, Robert E. W.; Franco, Octávio L.; Migliolo, Ludovico; Oliveira Nolasco Da Silva, Diego; de la Fuente Nunez, Cesar; ... Show more Show less
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Abstract
Due to the growing concern about antibiotic-resistant microbial infections, increasing support has been given to new drug discovery programs. A promising alternative to counter bacterial infections includes the antimicrobial peptides (AMPs), which have emerged as model molecules for rational design strategies. Here we focused on the study of Pa-MAP 1.9, a rationally designed AMP derived from the polar fish Pleuronectes americanus. Pa-MAP 1.9 was active against Gram-negative planktonic bacteria and biofilms, without being cytotoxic to mammalian cells. By using AFM, leakage assays, CD spectroscopy and in silico tools, we found that Pa-MAP 1.9 may be acting both on intracellular targets and on the bacterial surface, also being more efficient at interacting with anionic LUVs mimicking Gram-negative bacterial surface, where this peptide adopts α-helical conformations, than cholesterol-enriched LUVs mimicking mammalian cells. Thus, as bacteria present varied physiological features that favor antibiotic-resistance, Pa-MAP 1.9 could be a promising candidate in the development of tools against infections caused by pathogenic bacteria.
Date issued
2016-02
URI
http://hdl.handle.net/1721.1/108332
Department
Massachusetts Institute of Technology. Research Laboratory of Electronics
Journal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Cardoso, Marlon H.; Ribeiro, Suzana M.; Nolasco, Diego O.; de la Fuente-Núñez, César; Felício, Mário R.; Gonçalves, Sónia; Matos, Carolina O. et al. “A Polyalanine Peptide Derived from Polar Fish with Anti-Infectious Activities.” Scientific Reports 6 (February 26, 2016): 21385.
Version: Final published version
ISSN
2045-2322

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