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dc.contributor.authorSigova, A. A.
dc.contributor.authorAbraham, B. J.
dc.contributor.authorJi, X.
dc.contributor.authorMolinie, B.
dc.contributor.authorHannett, N. M.
dc.contributor.authorGuo, Y. E.
dc.contributor.authorGiallourakis, C. C.
dc.contributor.authorJangi, Mohini Rohit
dc.contributor.authorSharp, Phillip A.
dc.contributor.authorYoung, Richard A.
dc.date.accessioned2017-04-27T20:02:44Z
dc.date.available2017-04-27T20:02:44Z
dc.date.issued2015-11
dc.date.submitted2015-08
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttp://hdl.handle.net/1721.1/108470
dc.description.abstractTranscription factors (TFs) bind specific sequences in promoter-proximal and -distal DNA elements to regulate gene transcription. RNA is transcribed from both of these DNA elements, and some DNA binding TFs bind RNA. Hence, RNA transcribed from regulatory elements may contribute to stable TF occupancy at these sites. We show that the ubiquitously expressed TF Yin-Yang 1 (YY1) binds to both gene regulatory elements and their associated RNA species across the entire genome. Reduced transcription of regulatory elements diminishes YY1 occupancy, whereas artificial tethering of RNA enhances YY1 occupancy at these elements. We propose that RNA makes a modest but important contribution to the maintenance of certain TFs at gene regulatory elements and suggest that transcription of regulatory elements produces a positive-feedback loop that contributes to the stability of gene expression programs.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (HG002668)en_US
dc.description.sponsorshipBiogen, Inc.en_US
dc.language.isoen_US
dc.publisherAmerican Association for the Advancement of Science (AAAS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1126/science.aad3346en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleTranscription factor trapping by RNA in gene regulatory elementsen_US
dc.typeArticleen_US
dc.identifier.citationSigova, A. A. et al. “Transcription Factor Trapping by RNA in Gene Regulatory Elements.” Science 350.6263 (2015): 978–981.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorJangi, Mohini Rohit
dc.contributor.mitauthorSharp, Phillip A.
dc.contributor.mitauthorYoung, Richard A.
dc.relation.journalScienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsSigova, A. A.; Abraham, B. J.; Ji, X.; Molinie, B.; Hannett, N. M.; Guo, Y. E.; Jangi, M.; Giallourakis, C. C.; Sharp, P. A.; Young, R. A.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1465-1691
dc.identifier.orcidhttps://orcid.org/0000-0001-8855-8647
dspace.mitauthor.errortrue
mit.licensePUBLISHER_POLICYen_US


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