Precision mass measurements in solution reveal properties of single cells and bioparticles
Author(s)
Olcum, Selim A.; Cermak, Nathan; Manalis, Scott R
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Precise characterization of biological materials ranging from single cells (~1-20 microns) to extracellular vesicles (20-200 nm) is of fundamental interest because of their biological and translational value. Here we discuss the value of precision mass measurements in solution for informing various physical and biological parameters, such as mass accumulation rate, longitudinal cell growth or cell density. We introduce how the limits of the single-particle mass measurements can be pushed down to nano-scale dimensions enabling the resolution of extracellular vesicles and viruses in solution. We believe with future advancements on the precision and throughput of this approach, the capability of analyzing biologically relevant particles in solution will have broad biological and translational impact.
Date issued
2015-12Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering; Program in Media Arts and Sciences (Massachusetts Institute of Technology); Koch Institute for Integrative Cancer Research at MITJournal
2015 IEEE International Electron Devices Meeting (IEDM)
Publisher
Institute of Electrical and Electronics Engineers
Citation
Olcum, Selim, Nathan Cermak, and Scott R. Manalis. “Precision Mass Measurements in Solution Reveal Properties of Single Cells and Bioparticles.” 2015 IEEE International Electron Devices Meeting (IEDM) (December 2015).
Version: Author's final manuscript
ISBN
978-1-4673-9894-7