MIT Libraries homeMIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

Author(s)
Hollister-Locke, Jennifer; Bochenek, Matthew A; Dholakia, Nimit; Cohen, Josh; Siniakowicz, Karolina; Qi, Meirigeng; McGarrigle, James; Lyle, Stephen; Harlan, David M; Greiner, Dale L; Oberholzer, Jose; Weir, Gordon C; Vegas, Arturo; Veiseh, Omid; Doloff, Joshua C; Ma, Minglin; Tam, Hok Hei; Bratlie, Kaitlin M; Li, Jie; Bader, Andrew; Langan, Erin; Olejnik, Karsten; Fenton, Patrick; Kang, Jeon Woong; Chiu, Alan; Siebert, Sean M; Tang, Katherine; Jhunjhunwala, Siddharth; Aresta-Dasilva, Stephanie K; Thakrar, Raj; Vietti, Thema; Chen, Michael Y; Langer, Robert S; Anderson, Daniel Griffith; ... Show more Show less
Thumbnail
DownloadAnderson_Combinatorial hydrogel.pdf (2.401Mb)
PUBLISHER_POLICY

Publisher Policy

Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.

Terms of use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Metadata
Show full item record
Abstract
The foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient. There is a critical need for biomaterials that overcome this key challenge in the development of medical devices. Here we use a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate. We evaluated the materials in vivo and identified three triazole-containing analogs that substantially reduce foreign body reactions in both rodents and, for at least 6 months, in non-human primates. The distribution of the triazole modification creates a unique hydrogel surface that inhibits recognition by macrophages and fibrous deposition. In addition to the utility of the compounds reported here, our approach may enable the discovery of other materials that mitigate the foreign body response.
Date issued
2016-01
URI
http://hdl.handle.net/1721.1/109048
Department
Institute for Medical Engineering and Science; David H. Koch Institute for Integrative Cancer Research at MIT; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Division of Comparative Medicine; Massachusetts Institute of Technology. Spectroscopy Laboratory
Journal
Nature Biotechnology
Publisher
Nature Publishing Group
Citation
Vegas, Arturo J; Veiseh, Omid; Doloff, Joshua C; Ma, Minglin; Tam, Hok Hei; Bratlie, Kaitlin; Li, Jie, et al. “Combinatorial Hydrogel Library Enables Identification of Materials That Mitigate the Foreign Body Response in Primates.” Nature Biotechnology 34, no. 3 (January 2016): 345–352. © 2016 Nature America, Inc
Version: Author's final manuscript
ISSN
1087-0156
1546-1696

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries homeMIT Libraries logo

Find us on

Twitter Facebook Instagram YouTube RSS

MIT Libraries navigation

SearchHours & locationsBorrow & requestResearch supportAbout us
PrivacyPermissionsAccessibility
MIT
Massachusetts Institute of Technology
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.