Modeling the Electrophoretic Separation of Short Biological Molecules in Nanofluidic Devices
Author(s)Fayad, Ghassan; Hadjiconstantinou, Nicolas
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Via comparisons with rigid-rod and wormlike-chain Brownian dynamics (BD) simulations and the experimental results of Fu et al. (2006, “Molecular Sieving in Periodic Free-Energy Landscapes Created by Patterned Nanofilter Arrays,” Phys. Rev. Lett., 97(1), p. 018103), we demonstrate that, for the purposes of low-to-medium field electrophoretic separation, sufficiently short biomolecules can be modeled as point particles, with their orientational degrees of freedom accounted for using partition coefficients. This observation is used in the present work to build an efficient BD simulation method. Particular attention is paid to the model's ability to quantitatively capture experimental results using realistic values of all physical parameters.
DepartmentMassachusetts Institute of Technology. Department of Mechanical Engineering
Journal of Fluids Engineering
Fayad, Ghassan N. and Hadjiconstantinou, Nicolas G. “Modeling the Electrophoretic Separation of Short Biological Molecules in Nanofluidic Devices.” Journal of Fluids Engineering 135, no. 2 (March 2013): 024501. © 2013 ASME
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