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Discovery and Characterization of a Disulfide-Locked C[subscript 2]-Symmetric Defensin Peptide

dc.contributor.authorZiarek, Joshua J.
dc.contributor.authorWagner, Gerhard
dc.contributor.authorWommack, Andrew
dc.contributor.authorTomaras, Jill M
dc.contributor.authorChileveru, Haritha reddy
dc.contributor.authorZhang, Yunfei
dc.contributor.authorNolan, Elizabeth Marie
dc.date.accessioned2017-05-16T15:26:43Z
dc.date.available2017-05-16T15:26:43Z
dc.date.issued2014-09
dc.identifier.issn0002-7863
dc.identifier.issn1520-5126
dc.identifier.urihttp://hdl.handle.net/1721.1/109106
dc.description.abstractWe report the discovery of HD5-CD, an unprecedented C[subscript 2]-symmetric β-barrel-like covalent dimer of the cysteine-rich host-defense peptide human defensin 5 (HD5). Dimerization results from intermonomer disulfide exchange between the canonical α-defensin Cys[superscript II]–Cys[superscript IV] (Cys[superscript 5]–Cys[superscript 20]) bonds located at the hydrophobic interface. This disulfide-locked dimeric assembly provides a new element of structural diversity for cysteine-rich peptides as well as increased protease resistance, broad-spectrum antimicrobial activity, and enhanced potency against the opportunistic human pathogen Acinetobacter baumannii.en_US
dc.description.sponsorshipUnited States. National Institutes of Health (DP2OD007045)en_US
dc.description.sponsorshipUnited States. National Institutes of Health (PO1 GM047467)en_US
dc.description.sponsorshipUnited States. National Institutes of Health (F32GM103005)en_US
dc.description.sponsorshipUnited States. National Institutes of Health (EB-002026)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Grant NSF-007031)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/ja505957wen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceACSen_US
dc.titleDiscovery and Characterization of a Disulfide-Locked C[subscript 2]-Symmetric Defensin Peptideen_US
dc.typeArticleen_US
dc.identifier.citationWommack, Andrew J., Joshua J. Ziare, Jill Tomaras, Haritha R. Chileveru, Yunfei Zhang, Gerhard Wagner and Elizabeth M. Nolan. "Discovery and Characterization of a Disulfide-Locked C2-Symmetric Defensin Peptide." Journal of the American Chemical Society 136 (October 1 2014) (39): 13494–13497.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorWommack, Andrew
dc.contributor.mitauthorTomaras, Jill M
dc.contributor.mitauthorChileveru, Haritha reddy
dc.contributor.mitauthorZhang, Yunfei
dc.contributor.mitauthorNolan, Elizabeth Marie
dc.relation.journalJournal of the American Chemical Societyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsWommack, Andrew J.; Ziarek, Joshua J.; Tomaras, Jill; Chileveru, Haritha R.; Zhang, Yunfei; Wagner, Gerhard; Nolan, Elizabeth M.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-2515-5901
dc.identifier.orcidhttps://orcid.org/0000-0002-6426-2291
dc.identifier.orcidhttps://orcid.org/0000-0002-6153-8803
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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