| dc.contributor.author | Ziarek, Joshua J. | |
| dc.contributor.author | Wagner, Gerhard | |
| dc.contributor.author | Wommack, Andrew | |
| dc.contributor.author | Tomaras, Jill M | |
| dc.contributor.author | Chileveru, Haritha reddy | |
| dc.contributor.author | Zhang, Yunfei | |
| dc.contributor.author | Nolan, Elizabeth Marie | |
| dc.date.accessioned | 2017-05-16T15:26:43Z | |
| dc.date.available | 2017-05-16T15:26:43Z | |
| dc.date.issued | 2014-09 | |
| dc.identifier.issn | 0002-7863 | |
| dc.identifier.issn | 1520-5126 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/109106 | |
| dc.description.abstract | We report the discovery of HD5-CD, an unprecedented C[subscript 2]-symmetric β-barrel-like covalent dimer of the cysteine-rich host-defense peptide human defensin 5 (HD5). Dimerization results from intermonomer disulfide exchange between the canonical α-defensin Cys[superscript II]–Cys[superscript IV] (Cys[superscript 5]–Cys[superscript 20]) bonds located at the hydrophobic interface. This disulfide-locked dimeric assembly provides a new element of structural diversity for cysteine-rich peptides as well as increased protease resistance, broad-spectrum antimicrobial activity, and enhanced potency against the opportunistic human pathogen Acinetobacter baumannii. | en_US |
| dc.description.sponsorship | United States. National Institutes of Health (DP2OD007045) | en_US |
| dc.description.sponsorship | United States. National Institutes of Health (PO1 GM047467) | en_US |
| dc.description.sponsorship | United States. National Institutes of Health (F32GM103005) | en_US |
| dc.description.sponsorship | United States. National Institutes of Health (EB-002026) | en_US |
| dc.description.sponsorship | National Science Foundation (U.S.) (Grant NSF-007031) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/ja505957w | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | ACS | en_US |
| dc.title | Discovery and Characterization of a Disulfide-Locked C[subscript 2]-Symmetric Defensin Peptide | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Wommack, Andrew J., Joshua J. Ziare, Jill Tomaras, Haritha R.
Chileveru, Yunfei Zhang, Gerhard Wagner and Elizabeth M. Nolan. "Discovery and Characterization of a Disulfide-Locked C2-Symmetric Defensin Peptide." Journal of the American Chemical Society 136 (October 1 2014) (39): 13494–13497. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Wommack, Andrew | |
| dc.contributor.mitauthor | Tomaras, Jill M | |
| dc.contributor.mitauthor | Chileveru, Haritha reddy | |
| dc.contributor.mitauthor | Zhang, Yunfei | |
| dc.contributor.mitauthor | Nolan, Elizabeth Marie | |
| dc.relation.journal | Journal of the American Chemical Society | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Wommack, Andrew J.; Ziarek, Joshua J.; Tomaras, Jill; Chileveru, Haritha R.; Zhang, Yunfei; Wagner, Gerhard; Nolan, Elizabeth M. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-2515-5901 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-6426-2291 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-6153-8803 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
