Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms
Author(s)Brophy, Megan Brunjes; Nolan, Elizabeth Marie
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Bacterial and fungal pathogens cause a variety of infectious diseases and constitute a significant threat to public health. The human innate immune system represents the first line of defense against pathogenic microbes and employs a range of chemical artillery to combat these invaders. One important mechanism of innate immunity is the sequestration of metal ions that are essential nutrients. Manganese is one nutrient that is required for many pathogens to establish an infective lifestyle. This review summarizes recent advances in the role of manganese in the host–pathogen interaction and highlights Mn(II) sequestration by neutrophil calprotectin as well as how bacterial acquisition and utilization of manganese enables pathogenesis.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
ACS Chemical Biology
American Chemical Society (ACS)
Brophy, Megan Brunjes, and Elizabeth M. Nolan. “Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms.” ACS Chemical Biology 10, no. 3 (March 20, 2015): 641–651. © 2015 American Chemical Society.
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