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Bioinspired Nanoparticulate Medical Glues for Minimally Invasive Tissue Repair

Author(s)
Xu, Chenjie; Sebastin, Monisha; Lee, Albert; Holwell, Nathan; Xu, Calvin; Mu, Luye; Miranda-Nieves, David; Lee, Yuhan; Langer, Robert S; Lin, Charles; Karp, Jeffrey Michael; ... Show more Show less
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Abstract
Delivery of tissue glues through small-bore needles or trocars is critical for sealing holes, affixing medical devices, or attaching tissues together during minimally invasive surgeries. Inspired by the granule-packaged glue delivery system of sandcastle worms, a nanoparticulate formulation of a viscous hydrophobic light-activated adhesive based on poly(glycerol sebacate)-acrylate is developed. Negatively charged alginate is used to stabilize the nanoparticulate surface to significantly reduce its viscosity and to maximize injectability through small-bore needles. The nanoparticulate glues can be concentrated to ≈30 w/v% dispersions in water that remain localized following injection. With the trigger of a positively charged polymer (e.g., protamine), the nanoparticulate glues can quickly assemble into a viscous glue that exhibits rheological, mechanical, and adhesive properties resembling the native poly(glycerol sebacate)-acrylate based glues. This platform should be useful to enable the delivery of viscous glues to augment or replace sutures and staples during minimally invasive procedures.
Date issued
2015-11
URI
http://hdl.handle.net/1721.1/109410
Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Harvard University--MIT Division of Health Sciences and Technology; Koch Institute for Integrative Cancer Research at MIT
Journal
Advanced Healthcare Materials
Publisher
Wiley Blackwell
Citation
Lee, Yuhan; Xu, Chenjie; Sebastin, Monisha; Lee, Albert; Holwell, Nathan; Xu, Calvin; Miranda Nieves, David et al. “Bioinspired Nanoparticulate Medical Glues for Minimally Invasive Tissue Repair.” Advanced Healthcare Materials 4, no. 16 (July 2015): 2587–2596 © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Version: Author's final manuscript
ISSN
2192-2640

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