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Engineering Stem Cell Organoids

Author(s)
Safaee, Helia; Levy, Oren; Yin, Xiaolei; Mead, Benjamin Elliott; Langer, Robert S; Karp, Jeffrey Michael; ... Show more Show less
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Alternative title
Engineering Stem Cell Organoids
Terms of use
Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/
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Abstract
Organoid systems leverage the self-organizing properties of stem cells to create diverse multi-cellular tissue proxies. Most organoid models only represent single or partial components of a tissue, and it is often difficult to control the cell type, organization, and cell-cell/cell-matrix interactions within these systems. Herein, we discuss basic approaches to generate stem cell-based organoids, their advantages and limitations, and how bioengineering strategies can be used to steer the cell composition and their 3D organization within organoids to further enhance their utility in research and therapies.
Date issued
2016-01
URI
http://hdl.handle.net/1721.1/109414
Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
Journal
Cell Stem Cell
Publisher
Elsevier
Citation
Yin, Xiaolei; Mead, Benjamin E.; Safaee, Helia; Langer, Robert; Karp, Jeffrey M. and Levy, Oren. “Engineering Stem Cell Organoids.” Cell Stem Cell 18, no. 1 (January 2016): 25–38 © 2016 Elsevier Inc
Version: Author's final manuscript
ISSN
1934-5909

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