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Drosophila non-muscle myosin II motor activity determines the rate of tissue folding

Author(s)
Vasquez, Claudia G; Heissler, Sarah M; Billington, Neil; Sellers, James R; Martin, Adam C
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Abstract
Non-muscle cell contractility is critical for tissues to adopt shape changes. Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoskeleton networks, recent studies have questioned the importance of myosin motor activity cell and tissue shape changes. Here, combining the biochemical analysis of enzymatic and motile properties for purified myosin mutants with in vivo measurements of apical constriction for the same mutants, we show that in vivo constriction rate scales with myosin motor activity. We show that so-called phosphomimetic mutants of the Drosophila regulatory light chain (RLC) do not mimic the phosphorylated RLC state in vitro. The defect in the myosin motor activity in these mutants is evident in developing Drosophila embryos where tissue recoil following laser ablation is decreased compared to wild-type tissue. Overall, our data highlights that myosin activity is required for rapid cell contraction and tissue folding in developing Drosophila embryos.
Date issued
2016-12
URI
http://hdl.handle.net/1721.1/109465
Department
Massachusetts Institute of Technology. Department of Biology
Journal
eLife
Publisher
eLife Sciences Publications, Ltd.
Citation
Vasquez, Claudia G; Heissler, Sarah M; Billington, Neil; Sellers, James R and Martin, Adam C. “Drosophila Non-Muscle Myosin II Motor Activity Determines the Rate of Tissue Folding.” eLife 5 (December 2016): e20828
Version: Final published version
ISSN
2050-084X

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