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A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells

dc.contributor.authorSuntharalingam, Kogularamanan
dc.contributor.authorPatra, Malay
dc.contributor.authorJohnstone, Timothy
dc.contributor.authorLippard, Stephen J.
dc.date.accessioned2017-06-05T17:00:09Z
dc.date.available2017-06-05T17:00:09Z
dc.date.issued2016-02
dc.date.submitted2015-11
dc.identifier.issn0570-0833
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/1721.1/109592
dc.description.abstractThree rationally designed glucose–platinum conjugates (Glc–Pts) were synthesized and their biological activities evaluated. The Glc–Pts, 1–3, exhibit high levels of cytotoxicity toward a panel of cancer cells. The subcellular target and cellular uptake mechanism of the Glc–Pts were elucidated. For uptake into cells, Glc–Pt 1 exploits both glucose and organic cation transporters, both widely overexpressed in cancer. Compound 1 preferentially accumulates in and annihilates cancer, compared to normal epithelial, cells in vitro.en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (CA034992)en_US
dc.language.isoen_US
dc.publisherWiley Blackwellen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/anie.201510551en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleA Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cellsen_US
dc.typeArticleen_US
dc.identifier.citationPatra, Malay; Johnstone, Timothy C.; Suntharalingam, Kogularamanan and Lippard, Stephen J. “A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells.” Angewandte Chemie International Edition 55, no. 7 (January 2016): 2550–2554 © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistry
dc.contributor.mitauthorPatra, Malay
dc.contributor.mitauthorJohnstone, Timothy
dc.contributor.mitauthorLippard, Stephen J.
dc.relation.journalAngewandte Chemie International Editionen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsPatra, Malay; Johnstone, Timothy C.; Suntharalingam, Kogularamanan; Lippard, Stephen J.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-3373-6762
dc.identifier.orcidhttps://orcid.org/0000-0002-2693-4982
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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