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dc.contributor.authorBidone, Tamara Carla
dc.contributor.authorJung, Wonyeong
dc.contributor.authorMaruri, Daniel
dc.contributor.authorBorau, Carlos
dc.contributor.authorKim, Taeyoon
dc.contributor.authorKamm, Roger Dale
dc.date.accessioned2017-06-16T18:25:26Z
dc.date.available2017-06-16T18:25:26Z
dc.date.issued2017-01
dc.date.submitted2016-09
dc.identifier.issn1553-7358
dc.identifier.issn1553-734X
dc.identifier.urihttp://hdl.handle.net/1721.1/109969
dc.description.abstractCells assemble numerous types of actomyosin bundles that generate contractile forces for biological processes, such as cytokinesis and cell migration. One example of contractile bundles is a transverse arc that forms via actomyosin-driven condensation of actin filaments in the lamellipodia of migrating cells and exerts significant forces on the surrounding environments. Structural reorganization of a network into a bundle facilitated by actomyosin contractility is a physiologically relevant and biophysically interesting process. Nevertheless, it remains elusive how actin filaments are reoriented, buckled, and bundled as well as undergo tension buildup during the structural reorganization. In this study, using an agent-based computational model, we demonstrated how the interplay between the density of myosin motors and cross-linking proteins and the rigidity, initial orientation, and turnover of actin filaments regulates the morphological transformation of a cross-linked actomyosin network into a bundle and the buildup of tension occurring during the transformation.en_US
dc.language.isoen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1371/journal.pcbi.1005277en_US
dc.rightsCreative Commons Attribution 4.0 International Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourcePLoSen_US
dc.titleMorphological Transformation and Force Generation of Active Cytoskeletal Networksen_US
dc.typeArticleen_US
dc.identifier.citationBidone, Tamara Carla; Jung, Wonyeong; Maruri, Daniel; Borau, Carlos; Kamm, Roger D. and Kim, Taeyoon. “Morphological Transformation and Force Generation of Active Cytoskeletal Networks.” Edited by Anand R. Asthagiri. PLOS Computational Biology 13, no. 1 (January 2017): e1005277 © 2017 Bidone et alen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.mitauthorKamm, Roger Dale
dc.relation.journalPLoS Computational Biologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsBidone, Tamara Carla; Jung, Wonyeong; Maruri, Daniel; Borau, Carlos; Kamm, Roger D.; Kim, Taeyoonen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7232-304X
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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