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dc.contributor.authorBeyersmann, Paul G.
dc.contributor.authorSimon, Meinhard
dc.contributor.authorBrinkhoff, Thorsten
dc.contributor.authorTomasch, Jurgen
dc.contributor.authorGoker, Markus
dc.contributor.authorWagner-Dobler, Irene
dc.contributor.authorSon, Kwangmin
dc.contributor.authorStocker, Roman
dc.date.accessioned2017-06-16T19:51:22Z
dc.date.available2017-06-16T19:51:22Z
dc.date.issued2017-04
dc.date.submitted2016-11
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/1721.1/109983
dc.description.abstractAntibiotics are typically regarded as microbial weapons, but whereas their function at concentrations lethal for bacteria is often well characterized, the role of antibiotics at much lower concentrations as possibly found under natural conditions remains poorly understood. By using whole-transcriptome analyses and phenotypic screenings of the marine bacterium Phaeobacter inhibens we found that the broad-spectrum antibiotic tropodithietic acid (TDA) causes the same regulatory effects in quorum sensing (QS) as the common signaling molecule N-acyl-homoserine lactone (AHL) at concentrations 100-fold lower than the minimal inhibitory concentration against bacteria. Our results show that TDA has a significant impact on the expression of ~10% of the total genes of P. inhibens, in the same manner as the AHL. Furthermore, TDA needs the AHL associated LuxR-type transcriptional regulator, just as the AHL molecule. Low concentrations of antibiotics can obviously have a strong influence on the global gene expression of the bacterium that produces it and drastically change the metabolism and behaviour of the bacterium. For P. inhibens this includes motility, biofilm formation and antibiotic production, all important for settlement on new host-associated surfaces. Our results demonstrate that bacteria can produce antibiotics not only to antagonise other bacteria, but also to mediate QS like endogenous AHL molecules.en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/s41598-017-00784-7en_US
dc.rightsCreative Commons Attribution 4.0 International Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceNatureen_US
dc.titleDual function of tropodithietic acid as antibiotic and signaling molecule in global gene regulation of the probiotic bacterium Phaeobacter inhibensen_US
dc.typeArticleen_US
dc.identifier.citationBeyersmann, Paul G.; Tomasch, Jürgen; Son, Kwangmin; Stocker, Roman; Göker, Markus; Wagner-Döbler, Irene; Simon, Meinhard and Brinkhoff, Thorsten. “Dual Function of Tropodithietic Acid as Antibiotic and Signaling Molecule in Global Gene Regulation of the Probiotic Bacterium Phaeobacter Inhibens.” Scientific Reports 7, no. 1 (April 2017): 730 © 2017 Macmillan Publishers Limited, part of Springer Natureen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Civil and Environmental Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.mitauthorSon, Kwangmin
dc.contributor.mitauthorStocker, Roman
dc.relation.journalScientific Reportsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsBeyersmann, Paul G.; Tomasch, Jürgen; Son, Kwangmin; Stocker, Roman; Göker, Markus; Wagner-Döbler, Irene; Simon, Meinhard; Brinkhoff, Thorstenen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-8886-7455
dc.identifier.orcidhttps://orcid.org/0000-0002-3199-0508
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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