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dc.contributor.authorCorrea-de-Araujo, Rosaly
dc.contributor.authorHarris-Love, Michael O.
dc.contributor.authorMiljkovic, Iva
dc.contributor.authorFragala, Maren S.
dc.contributor.authorManini, Todd M.
dc.contributor.authorAnthony, Brian
dc.date.accessioned2017-06-21T13:28:48Z
dc.date.available2017-06-21T13:28:48Z
dc.date.issued2017-02
dc.date.submitted2016-11
dc.identifier.issn1664-042X
dc.identifier.urihttp://hdl.handle.net/1721.1/110099
dc.description.abstractA growing body of scientific literature suggests that not only changes in skeletal muscle mass, but also other factors underpinning muscle quality, play a role in the decline in skeletal muscle function and impaired mobility associated with aging. A symposium on muscle quality and the need for standardized assessment was held on April 28, 2016 at the International Conference on Frailty and Sarcopenia Research in Philadelphia, Pennsylvania. The purpose of this symposium was to provide a venue for basic science and clinical researchers and expert clinicians to discuss muscle quality in the context of skeletal muscle function deficit and other aging-related muscle dysfunctions. The present article provides an expanded introduction concerning the emerging definitions of muscle quality and a potential framework for scientific inquiry within the field. Changes in muscle tissue composition, based on excessive levels of inter- and intra-muscular adipose tissue and intramyocellular lipids, have been found to adversely impact metabolism and peak force generation. However, methods to easily and rapidly assess muscle tissue composition in multiple clinical settings and with minimal patient burden are needed. Diagnostic ultrasound and other assessment methods continue to be developed for characterizing muscle pathology, and enhanced sonography using sensors to provide user feedback and improve reliability is currently the subject of ongoing investigation and development. In addition, measures of relative muscle force such as specific force or grip strength adjusted for body size have been proposed as methods to assess changes in muscle quality. Furthermore, performance-based assessments of muscle power via timed tests of function and body size estimates, are associated with lower extremity muscle strength may be responsive to age-related changes in muscle quality. Future aims include reaching consensus on the definition and standardized assessments of muscle quality, and providing recommendations to address critical clinical and technology research gaps within the field.en_US
dc.description.sponsorshipUnited States. Dept. of Veterans Affairs. Rehabilitation Research and Development Service (1IK2RX001854-01)en_US
dc.language.isoen_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.isversionofhttp://dx.doi.org/10.3389/fphys.2017.00087en_US
dc.rightsCreative Commons Attribution 4.0 International Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceFrontiersen_US
dc.titleThe Need for Standardized Assessment of Muscle Quality in Skeletal Muscle Function Deficit and Other Aging-Related Muscle Dysfunctions: A Symposium Reporten_US
dc.typeArticleen_US
dc.identifier.citationCorrea-de-Araujo, Rosaly; Harris-Love, Michael O.; Miljkovic, Iva; Fragala, Maren S.; Anthony, Brian W. and Manini, Todd M. “The Need for Standardized Assessment of Muscle Quality in Skeletal Muscle Function Deficit and Other Aging-Related Muscle Dysfunctions: A Symposium Report.” Frontiers in Physiology 8 (February 2017): 87 © 2017 Correa-de-Araujo, Harris-Love, Miljkovic, Fragala, Anthony and Manini.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Laboratory for Manufacturing and Productivityen_US
dc.contributor.mitauthorAnthony, Brian
dc.relation.journalFrontiers in Physiologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsCorrea-de-Araujo, Rosaly; Harris-Love, Michael O.; Miljkovic, Iva; Fragala, Maren S.; Anthony, Brian W.; Manini, Todd M.en_US
dspace.embargo.termsNen_US
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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