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dc.contributor.authorMartel, An
dc.contributor.authorVerbrugghe, Elin
dc.contributor.authorDucatelle, Richard
dc.contributor.authorLongcore, Joyce E.
dc.contributor.authorJames, Timothy Y.
dc.contributor.authorPasmans, Frank
dc.contributor.authorFisher, Matthew C.
dc.contributor.authorFarrer, Rhys
dc.contributor.authorAbouelleil, Amr M
dc.contributor.authorCuomo, Christina A
dc.date.accessioned2017-06-21T14:12:45Z
dc.date.available2017-06-21T14:12:45Z
dc.date.issued2017-03
dc.date.submitted2016-07
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/1721.1/110107
dc.description.abstractTo understand the evolutionary pathways that lead to emerging infections of vertebrates, here we explore the genomic innovations that allow free-living chytrid fungi to adapt to and colonize amphibian hosts. Sequencing and comparing the genomes of two pathogenic species of Batrachochytrium to those of close saprophytic relatives reveals that pathogenicity is associated with remarkable expansions of protease and cell wall gene families, while divergent infection strategies are linked to radiations of lineage-specific gene families. By comparing the host–pathogen response to infection for both pathogens, we illuminate the traits that underpin a strikingly different immune response within a shared host species. Our results show that, despite commonalities that promote infection, specific gene-family radiations contribute to distinct infection strategies. The breadth and evolutionary novelty of candidate virulence factors that we discover underscores the urgent need to halt the advance of pathogenic chytrids and prevent incipient loss of biodiversity.en_US
dc.description.sponsorshipNational Human Genome Research Institute (U.S.) (U54HG003067)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/ncomms14742en_US
dc.rightsCreative Commons Attribution 4.0 International Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceNatureen_US
dc.titleGenomic innovations linked to infection strategies across emerging pathogenic chytrid fungien_US
dc.typeArticleen_US
dc.identifier.citationFarrer, Rhys A.; Martel, An; Verbrugghe, Elin; Abouelleil, Amr; Ducatelle, Richard; Longcore, Joyce E.; James, Timothy Y.; Pasmans, Frank; Fisher, Matthew C. and Cuomo, Christina A. “Genomic Innovations Linked to Infection Strategies Across Emerging Pathogenic Chytrid Fungi.” Nature Communications 8 (March 2017): 14742 © 2017 The Authorsen_US
dc.contributor.departmentBroad Institute of MIT and Harvarden_US
dc.contributor.mitauthorFarrer, Rhys
dc.contributor.mitauthorAbouelleil, Amr M
dc.contributor.mitauthorCuomo, Christina A
dc.relation.journalNature Communicationsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsFarrer, Rhys A.; Martel, An; Verbrugghe, Elin; Abouelleil, Amr; Ducatelle, Richard; Longcore, Joyce E.; James, Timothy Y.; Pasmans, Frank; Fisher, Matthew C.; Cuomo, Christina A.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-3710-9881
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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