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dc.contributor.authorKutay, Ulrike
dc.contributor.authorSchwartz, Thomas
dc.contributor.authorSosa, Brian A.
dc.date.accessioned2017-06-27T19:28:54Z
dc.date.available2017-06-27T19:28:54Z
dc.date.issued2013-04
dc.identifier.issn0959-440X
dc.identifier.urihttp://hdl.handle.net/1721.1/110334
dc.description.abstractCommunication between nucleus and cytoplasm extends past molecular exchange and critically includes mechanical wiring. Cytoskeleton and nucleoskeleton are connected via molecular tethers that span the nuclear envelope. Sad1, UNC84 (SUN)-domain proteins spanning the inner nuclear membrane and Klarsicht, ANC-1 and SYNE/Nesprin-1 and -2 Homology (KASH)-peptide bearing proteins residing in the outer nuclear membrane directly bind and constitute the core of the LInkers of Nucleoskeleton and Cytoskeleton (LINC) complex. These connections appear critical for a growing number of biological processes and aberrations are implicated in a host of diverse diseases, including muscular dystrophies, cardiomyopathies, and premature aging. We discuss recent developments in this vibrant research area, particularly in context of first structural insights into LINC complexes reported in the past year.en_US
dc.description.sponsorshipNational Institute of Neurological Disorders and Stroke (U.S.) (grant R21 NS075883)en_US
dc.description.sponsorshipDystonia Medical Research Foundationen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.sbi.2013.03.005en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleStructural insights into LINC complexesen_US
dc.typeArticleen_US
dc.identifier.citationSosa, Brian A, Ulrike Kutay, and Thomas U Schwartz. “Structural Insights into LINC Complexes.” Current Opinion in Structural Biology 23, no. 2 (April 2013): 285–291.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorSchwartz, Thomas
dc.contributor.mitauthorSosa-Alvarado, Brian Alexander
dc.relation.journalCurrent Opinion in Structural Biologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsSosa, Brian A; Kutay, Ulrike; Schwartz, Thomas Uen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-8012-1512
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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