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dc.contributor.authorBersini, S.
dc.contributor.authorMoretti, Matteo
dc.contributor.authorJeon, Jessie S
dc.contributor.authorKamm, Roger Dale
dc.date.accessioned2017-06-29T17:46:33Z
dc.date.available2017-06-29T17:46:33Z
dc.date.issued2014-06
dc.identifier.issn1359-6446
dc.identifier.urihttp://hdl.handle.net/1721.1/110374
dc.description.abstractA crucial event in the metastatic cascade is the extravasation of circulating cancer cells from blood capillaries to the surrounding tissues. The past 5 years have been characterized by a significant evolution in the development of in vitro extravasation models, which moved from traditional transmigration chambers to more sophisticated microfluidic devices, enabling the study of complex cell–cell and cell–matrix interactions in multicellular, controlled environments. These advanced assays could be applied to screen easily and rapidly a broad spectrum of molecules inhibiting cancer cell endothelial adhesion and extravasation, thus contributing to the design of more focused in vivo tests.en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (R33 CA174550-01)en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (R21 CA140096)en_US
dc.description.sponsorshipRepligen Corporation (Repligen Fellowship in Cancer Research)en_US
dc.description.sponsorshipCharles Stark Draper Laboratory (Draper Fellowship)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.drudis.2013.12.006en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleIn vitro models of the metastatic cascade: from local invasion to extravasationen_US
dc.typeArticleen_US
dc.identifier.citationBersini, S., J.S. Jeon, Matteo Moretti, and R.D. Kamm. “In Vitro Models of the Metastatic Cascade: From Local Invasion to Extravasation.” Drug Discovery Today 19, no. 6 (June 2014): 735–742.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.mitauthorJeon, Jessie S
dc.contributor.mitauthorKamm, Roger Dale
dc.relation.journalDrug Discovery Todayen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsBersini, S.; Jeon, J.S.; Moretti, Matteo; Kamm, R.D.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7232-304X
mit.licensePUBLISHER_CCen_US


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