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Necroptosis-Inducing Rhenium(V) Oxo Complexes

dc.contributor.authorSuntharalingam, Kogularamanan
dc.contributor.authorAwuah, Samuel
dc.contributor.authorBruno, Peter Michael
dc.contributor.authorJohnstone, Timothy
dc.contributor.authorWang, Fang
dc.contributor.authorLin, Wei
dc.contributor.authorZheng, Yaorong
dc.contributor.authorPage, Julia E.
dc.contributor.authorHemann, Michael
dc.contributor.authorLippard, Stephen J.
dc.date.accessioned2017-07-03T13:47:29Z
dc.date.available2017-07-03T13:47:29Z
dc.date.issued2015-02
dc.identifier.issn0002-7863
dc.identifier.issn1520-5126
dc.identifier.urihttp://hdl.handle.net/1721.1/110417
dc.description.abstractRhenium(V) oxo complexes of general formula [ReO(OMe)(N^N)Cl₂], where N^N = 4,7-diphenyl-1,10-phenanthroline, 1, or 3,4,7,8-tetramethyl-1,10-phenanthroline, 2, effectively kill cancer cells by triggering necroptosis, a non-apoptotic form of cell death. Both complexes evoke necrosome (RIP1-RIP3)-dependent intracellular reactive oxygen species (ROS) production and propidium iodide uptake. The complexes also induce mitochondrial membrane potential depletion, a possible downstream effect of ROS production. Apparently, 1 and 2 are the first rhenium complexes to evoke cellular events consistent with programmed necrosis in cancer cells. Furthermore, 1 and 2 display low acute toxicity in C57BL/6 mice and reasonable stability in fresh human blood.en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (CA034992)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/ja511978yen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleNecroptosis-Inducing Rhenium(V) Oxo Complexesen_US
dc.typeArticleen_US
dc.identifier.citationSuntharalingam, Kogularamanan; Awuah, Samuel G.; Bruno, Peter M.; Johnstone, Timothy C.; Wang, Fang; Lin, Wei; Zheng, Yao-Rong; Page, Julia E.; Hemann, Michael T. and Lippard, Stephen J. “Necroptosis-Inducing Rhenium(V) Oxo Complexes.” Journal of the American Chemical Society 137, 8 (March 2015): 2967–2974 © 2015 American Chemical Societyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorSuntharalingam, Kogularamanan
dc.contributor.mitauthorAwuah, Samuel
dc.contributor.mitauthorBruno, Peter Michael
dc.contributor.mitauthorJohnstone, Timothy
dc.contributor.mitauthorWang, Fang
dc.contributor.mitauthorLin, Wei
dc.contributor.mitauthorZheng, Yaorong
dc.contributor.mitauthorPage, Julia E.
dc.contributor.mitauthorHemann, Michael
dc.contributor.mitauthorLippard, Stephen J.
dc.relation.journalJournal of the American Chemical Societyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsSuntharalingam, Kogularamanan; Awuah, Samuel G.; Bruno, Peter M.; Johnstone, Timothy C.; Wang, Fang; Lin, Wei; Zheng, Yao-Rong; Page, Julia E.; Hemann, Michael T.; Lippard, Stephen J.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-6958-3991
dc.identifier.orcidhttps://orcid.org/0000-0003-3383-0118
dc.identifier.orcidhttps://orcid.org/0000-0002-9192-6858
dc.identifier.orcidhttps://orcid.org/0000-0002-2693-4982
mit.licensePUBLISHER_POLICYen_US


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