| dc.contributor.author | Radford, Robert John | |
| dc.contributor.author | Lippard, Stephen J. | |
| dc.date.accessioned | 2017-07-03T14:40:56Z | |
| dc.date.available | 2017-07-03T14:40:56Z | |
| dc.date.issued | 2013-03 | |
| dc.identifier.issn | 1367-5931 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/110419 | |
| dc.description.abstract | The physiology and pathology of mobile zinc signaling has become an important topic in metalloneurochemistry. To study the action of mobile zinc effectively, specialized tools are required that probe the temporal and positional changes of zinc ions within live tissue and cells. In the present article we describe the design and implementation of selective zinc chelators as antagonists to interrogate the function of mobile zinc, with an emphasis on the pools of vesicular zinc in the terminals of hippocampal mossy fiber buttons.
Highlights
► Background on zinc metalloneurochemistry with an emphasis on hippocampal zinc. ► Design rules for zinc chelators that can be used as antagonists for mobile zinc. ► Utility of Zn-selective chelators for understanding zinc metalloneurochemisty. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (GM065519) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.cbpa.2013.01.009 | en_US |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Chelators for investigating zinc metalloneurochemistry | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Radford, Robert J and Lippard, Stephen J. “Chelators for Investigating Zinc Metalloneurochemistry.” Current Opinion in Chemical Biology 17, 2 (April 2013): 129–136 © 2013 Elsevier Ltd | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Radford, Robert John | |
| dc.contributor.mitauthor | Lippard, Stephen J. | |
| dc.relation.journal | Current Opinion in Chemical Biology | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Radford, Robert J; Lippard, Stephen J | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-2693-4982 | |
| mit.license | PUBLISHER_CC | en_US |
