dc.contributor.author | Cohen, Daniel Tzvi | |
dc.contributor.author | Buchwald, Stephen Leffler | |
dc.date.accessioned | 2017-07-05T14:23:50Z | |
dc.date.available | 2017-07-05T14:23:50Z | |
dc.date.issued | 2015-01 | |
dc.date.submitted | 2014-11 | |
dc.identifier.issn | 1523-7060 | |
dc.identifier.issn | 1523-7052 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/110448 | |
dc.description.abstract | A mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)aryl halides have required higher temperatures to achieve good catalytic activity. This current reaction allows the cyanation of a general scope of (hetero)aryl halides and triflates at 2–5 mol % catalyst loadings with temperatures ranging from rt to 40 °C. This mild method was applied to the synthesis of lersivirine, a reverse transcriptase inhibitor. | en_US |
dc.description.sponsorship | National Institutes of Health (GM46059) | en_US |
dc.description.sponsorship | National Institutes of Health (GM108294) | en_US |
dc.language.iso | en_US | |
dc.publisher | American Chemical Society (ACS) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1021/ol5032359 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | ACS | en_US |
dc.title | Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Cohen, Daniel T., and Stephen L. Buchwald. “Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media.” Organic Letters 17, 2 (January 2015): 202–205 © 2015 American Chemical Society | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.mitauthor | Cohen, Daniel Tzvi | |
dc.contributor.mitauthor | Buchwald, Stephen Leffler | |
dc.relation.journal | Organic Letters | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Cohen, Daniel T.; Buchwald, Stephen L. | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-7703-424X | |
dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
mit.license | PUBLISHER_POLICY | en_US |