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dc.contributor.authorCohen, Daniel Tzvi
dc.contributor.authorBuchwald, Stephen Leffler
dc.date.accessioned2017-07-05T14:23:50Z
dc.date.available2017-07-05T14:23:50Z
dc.date.issued2015-01
dc.date.submitted2014-11
dc.identifier.issn1523-7060
dc.identifier.issn1523-7052
dc.identifier.urihttp://hdl.handle.net/1721.1/110448
dc.description.abstractA mild, efficient, and low-temperature palladium-catalyzed cyanation of (hetero)aryl halides and triflates is reported. Previous palladium-catalyzed cyanations of (hetero)aryl halides have required higher temperatures to achieve good catalytic activity. This current reaction allows the cyanation of a general scope of (hetero)aryl halides and triflates at 2–5 mol % catalyst loadings with temperatures ranging from rt to 40 °C. This mild method was applied to the synthesis of lersivirine, a reverse transcriptase inhibitor.en_US
dc.description.sponsorshipNational Institutes of Health (GM46059)en_US
dc.description.sponsorshipNational Institutes of Health (GM108294)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/ol5032359en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceACSen_US
dc.titleMild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Mediaen_US
dc.typeArticleen_US
dc.identifier.citationCohen, Daniel T., and Stephen L. Buchwald. “Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media.” Organic Letters 17, 2 (January 2015): 202–205 © 2015 American Chemical Societyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorCohen, Daniel Tzvi
dc.contributor.mitauthorBuchwald, Stephen Leffler
dc.relation.journalOrganic Lettersen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsCohen, Daniel T.; Buchwald, Stephen L.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-7703-424X
dc.identifier.orcidhttps://orcid.org/0000-0003-3875-4775
mit.licensePUBLISHER_POLICYen_US


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