Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines

Author(s)
Ascic, Erhad; Buchwald, Stephen Leffler
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Abstract
A diastereo- and enantioselective CuH-catalyzed method for the preparation of highly functionalized indolines is reported. The mild reaction conditions and high degree of functional group compatibility as demonstrated with substrates bearing heterocycles, olefins, and substituted aromatic groups, renders this technique highly valuable for the synthesis of a variety of cis-2,3-disubstituted indolines in high yield and enantioeselectivity.
Date issued
2015-03
URI
http://hdl.handle.net/1721.1/110473
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Ascic, Erhad, and Stephen L. Buchwald. “Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines.” Journal of the American Chemical Society 137.14 (2015): 4666–4669. © 2015 American Chemical Society
Version: Final published version
ISSN
0002-7863
1520-5126
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