Design of New Ligands for the Palladium-Catalyzed Arylation of α-Branched Secondary Amines
Author(s)Park, Nathaniel Hamilton; Vinogradova, Ekaterina V.; Surry, David S; Buchwald, Stephen Leffler
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In Pd-catalyzed C[BOND]N cross-coupling reactions, α-branched secondary amines are difficult coupling partners and the desired products are often produced in low yields. In order to provide a robust method for accessing N-aryl α-branched tertiary amines, new catalysts have been designed to suppress undesired side reactions often encountered when these amine nucleophiles are used. These advances enabled the arylation of a wide array of sterically encumbered amines, highlighting the importance of rational ligand design in facilitating challenging Pd-catalyzed cross-coupling reactions.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Angewandte Chemie International Edition
Park, Nathaniel H. et al. “Design of New Ligands for the Palladium-Catalyzed Arylation of α-Branched Secondary Amines.” Angewandte Chemie International Edition 54.28 (2015): 8259–8262.
Author's final manuscript