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dc.contributor.authorYannas, Ioannis V
dc.contributor.authorTzeranis, Dimitrios
dc.contributor.authorSo, Peter T. C.
dc.date.accessioned2017-07-12T15:28:59Z
dc.date.available2017-07-12T15:28:59Z
dc.date.issued2015-12
dc.date.submitted2015-06
dc.identifier.issn1748-605X
dc.identifier.urihttp://hdl.handle.net/1721.1/110668
dc.description.abstractWe review the details of preparation and of the recently elucidated mechanism of biological (regenerative) activity of a collagen scaffold (dermis regeneration template, DRT) that has induced regeneration of skin and peripheral nerves (PN) in a variety of animal models and in the clinic. DRT is a 3D protein network with optimized pore size in the range 20–125 µm, degradation half-life 14 ± 7 d and ligand densities that exceed 200 µM α1β1 or α2β1 ligands. The pore has been optimized to allow migration of contractile cells (myofibroblasts, MFB) into the scaffold and to provide sufficient specific surface for cell–scaffold interaction; the degradation half-life provides the required time window for satisfactory binding interaction of MFB with the scaffold surface; and the ligand density supplies the appropriate ligands for specific binding of MFB on the scaffold surface. A dramatic change in MFB phenotype takes place following MFB-scaffold binding which has been shown to result in blocking of wound contraction. In both skin wounds and PN wounds the evidence has shown clearly that contraction blocking by DRT is followed by induction of regeneration of nearly perfect organs. The biologically active structure of DRT is required for contraction blocking; well-matched collagen scaffold controls of DRT, with structures that varied from that of DRT, have failed to induce regeneration. Careful processing of collagen scaffolds is required for adequate biological activity of the scaffold surface. The newly understood mechanism provides a relatively complete paradigm of regenerative medicine that can be used to prepare scaffolds that may induce regeneration of other organs in future studies.en_US
dc.language.isoen_US
dc.publisherIOP Publishingen_US
dc.relation.isversionofhttp://dx.doi.org/10.1088/1748-6041/11/1/014106en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceProf. Yannas via Angie Locknaren_US
dc.titleSurface biology of collagen scaffold explains blocking of wound contraction and regeneration of skin and peripheral nervesen_US
dc.typeArticleen_US
dc.identifier.citationYannas, IV, D Tzeranis, and P T So. “Surface Biology of Collagen Scaffold Explains Blocking of Wound Contraction and Regeneration of Skin and Peripheral Nerves.” Biomedical Materials 11, no. 1 (December 23, 2015): 014106.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.approverYannas, Ioannis V.en_US
dc.contributor.mitauthorYannas, Ioannis V
dc.contributor.mitauthorTzeranis, Dimitrios
dc.contributor.mitauthorSo, Peter T. C.
dc.relation.journalBiomedical Materialsen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsYannas, IV; Tzeranis, D; So, P Ten_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-0151-708X
dc.identifier.orcidhttps://orcid.org/0000-0003-4698-6488
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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