dc.contributor.author | Yang, Yunlong | |
dc.contributor.author | Andersson, Patrik | |
dc.contributor.author | Hosaka, Kayoko | |
dc.contributor.author | Zhang, Yin | |
dc.contributor.author | Cao, Renhai | |
dc.contributor.author | Iwamoto, Hideki | |
dc.contributor.author | Yang, Xiaojuan | |
dc.contributor.author | Nakamura, Masaki | |
dc.contributor.author | Wang, Jian | |
dc.contributor.author | Zhuang, Rujie | |
dc.contributor.author | Morikawa, Hiromasa | |
dc.contributor.author | Braun, Harald | |
dc.contributor.author | Beyaert, Rudi | |
dc.contributor.author | Samani, Nilesh | |
dc.contributor.author | Nakae, Susumu | |
dc.contributor.author | Hams, Emily | |
dc.contributor.author | Dissing, Steen | |
dc.contributor.author | Fallon, Padraic G. | |
dc.contributor.author | Cao, Yihai | |
dc.contributor.author | Xue, Yuan | |
dc.contributor.author | Langer, Robert S | |
dc.date.accessioned | 2017-07-12T15:49:30Z | |
dc.date.available | 2017-07-12T15:49:30Z | |
dc.date.issued | 2016-05 | |
dc.date.submitted | 2016-01 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/110671 | |
dc.description.abstract | Signalling molecules and pathways that mediate crosstalk between various tumour cellular compartments in cancer metastasis remain largely unknown. We report a mechanism of the interaction between perivascular cells and tumour-associated macrophages (TAMs) in promoting metastasis through the IL-33–ST2-dependent pathway in xenograft mouse models of cancer. IL-33 is the highest upregulated gene through activation of SOX7 transcription factor in PDGF-BB-stimulated pericytes. Gain- and loss-of-function experiments validate that IL-33 promotes metastasis through recruitment of TAMs. Pharmacological inhibition of the IL-33–ST2 signalling by a soluble ST2 significantly inhibits TAMs and metastasis. Genetic deletion of host IL-33 in mice also blocks PDGF-BB-induced TAM recruitment and metastasis. These findings shed light on the role of tumour stroma in promoting metastasis and have therapeutic implications for cancer therapy. | en_US |
dc.language.iso | en_US | |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1038/ncomms11385 | en_US |
dc.rights | Creative Commons Attribution 4.0 International License | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.source | Nature | en_US |
dc.title | The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Yang, Yunlong et al. “The PDGF-BB-SOX7 Axis-Modulated IL-33 in Pericytes and Stromal Cells Promotes Metastasis through Tumour-Associated Macrophages.” Nature Communications 7 (2016): 11385. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Institute for Medical Engineering & Science | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
dc.contributor.mitauthor | Xue, Yuan | |
dc.contributor.mitauthor | Langer, Robert S | |
dc.relation.journal | Nature Communications | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Yang, Yunlong; Andersson, Patrik; Hosaka, Kayoko; Zhang, Yin; Cao, Renhai; Iwamoto, Hideki; Yang, Xiaojuan; Nakamura, Masaki; Wang, Jian; Zhuang, Rujie; Morikawa, Hiromasa; Xue, Yuan; Braun, Harald; Beyaert, Rudi; Samani, Nilesh; Nakae, Susumu; Hams, Emily; Dissing, Steen; Fallon, Padraic G.; Langer, Robert; Cao, Yihai | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-4255-0492 | |
mit.license | PUBLISHER_CC | en_US |
mit.metadata.status | Complete | |