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Towards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage

Author(s)
Huang, Sha; Hou, Han Wei; Kanias, Tamir; Sertorio, Jonas Tadeu; Chen, Huichao; Sinchar, Derek; Gladwin, Mark T.; Han, Jongyoon; ... Show more Show less
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Abstract
In this study, the effects of prolonged storage on several biophysical properties of red blood cells (RBCs) were investigated. Single cell deformability was used as an important criterion in determining subgroups of RBCs evolved during storage lesion. A deformability-based microfluidic cell sorting technology was applied, which demonstrates the ability to enrich and separate the less deformable subpopulations of stored blood. These less deformable RBC subpopulations were then associated with other important markers such as osmotic fragility indicating cell integrity as well as microparticle content. This work demonstrates a systematic methodology to both monitor and improve banked blood quality, thereby reducing risks related to blood transfusion.
Date issued
2014-11
URI
http://hdl.handle.net/1721.1/110939
Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Research Laboratory of Electronics
Journal
Lab on a Chip
Publisher
Royal Society of Chemistry, The
Citation
Huang, Sha et al. “Towards Microfluidic-Based Depletion of Stiff and Fragile Human Red Cells That Accumulate During Blood Storage.” Lab Chip 15, 2 (January 2015): 448–458 © 2015 The Royal Society of Chemistry
Version: Author's final manuscript
ISSN
1473-0197
1473-0189

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