Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid–Glucose Complexation
Author(s)Dong, Yizhou; Xue, Kun; Weir, Gordon C.; Wang, Weiheng; Veiseh, Omid; Appel, Eric; Webber, Matthew; Tang, Benjamin C.; Yang, Xiwen; Langer, Robert S; Anderson, Daniel Griffith; ... Show more Show less
MetadataShow full item record
Injectable hydrogels have been widely used for a number of biomedical applications. Here, we report a new strategy to form an injectable and glucose-responsive hydrogel using the boronic acid–glucose complexation. The ratio of boronic acid and glucose functional groups is critical for hydrogel formation. In our system, polymers with 10–60% boronic acid, with the balance being glucose-modified, are favorable to form hydrogels. These hydrogels are shear-thinning and self-healing, recovering from shear-induced flow to a gel state within seconds. More importantly, these polymers displayed glucose-responsive release of an encapsulated model drug. The hydrogel reported here is an injectable and glucose-responsive hydrogel constructed from the complexation of boronic acid and glucose within a single component polymeric material.
DepartmentInstitute for Medical Engineering and Science; Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemical Engineering; Koch Institute for Integrative Cancer Research at MIT
American Chemical Society (ACS)
Dong, Yizhou et al. “Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid–Glucose Complexation.” Langmuir 32, 34 (August 2016): 8743–8747 © 2016 American Chemical Society
Author's final manuscript