| dc.contributor.author | Zheng, Tengfei | |
| dc.contributor.author | Nolan, Elizabeth Marie | |
| dc.date.accessioned | 2017-10-31T14:29:01Z | |
| dc.date.available | 2017-10-31T14:29:01Z | |
| dc.date.issued | 2015-02 | |
| dc.date.submitted | 2015-02 | |
| dc.identifier.issn | 0960-894X | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/112091 | |
| dc.description.abstract | The syntheses of five ciprofloxacin-modified (acyloxyl)alkyl esters and two siderophore–ciprofloxacin conjugates based on enterobactin that harbor such hydrolyzable linkages are reported. The hydrolytic stabilities of ciprofloxacin-modified (acyloxy)alkyl esters, evaluated at pH 7.5 and 30 °C, vary by >370-fold depending on the substituents in the vicinity of the ester linkage. | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.bmcl.2015.02.034 | en_US |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.source | Prof. Nolan via Erja Kajosalo | en_US |
| dc.title | Evaluation of (acyloxy)alkyl ester linkers for antibiotic release from siderophore–antibiotic conjugates | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Zheng, Tengfei, and Nolan, Elizabeth M. “Evaluation of (acyloxy)alkyl Ester Linkers for Antibiotic Release from Siderophore–antibiotic Conjugates.” Bioorganic & Medicinal Chemistry Letters 25, 21 (November 2015): 4987–4991 © 2015 Elsevier Ltd | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.approver | Nolan, Elizabeth M. | en_US |
| dc.contributor.mitauthor | Zheng, Tengfei | |
| dc.contributor.mitauthor | Nolan, Elizabeth Marie | |
| dc.relation.journal | Bioorganic & Medicinal Chemistry Letters | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Zheng, Tengfei; Nolan, Elizabeth M. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-6153-8803 | |
| mit.license | PUBLISHER_CC | en_US |
