Show simple item record

dc.contributor.authorChai, Xiaoqian
dc.contributor.authorOfen, Noa
dc.contributor.authorGabrieli, John D. E.
dc.contributor.authorWhitfield-Gabrieli, Susan
dc.date.accessioned2017-11-09T18:24:41Z
dc.date.available2017-11-09T18:24:41Z
dc.date.issued2013-09
dc.date.submitted2013-09
dc.identifier.issn1053-8119
dc.identifier.urihttp://hdl.handle.net/1721.1/112159
dc.description.abstractTask-induced deactivation of the default-mode network (DMN) has been associated in adults with successful episodic memory formation, possibly as a mechanism to focus allocation of mental resources for successful encoding of external stimuli. We investigated developmental changes of deactivation of the DMN (posterior cingulate, medial prefrontal, and bilateral lateral parietal cortices) during episodic memory formation in children, adolescents, and young adults (ages 8–24), who studied scenes during functional magnetic resonance imaging (fMRI). Recognition memory improved with age. We defined DMN regions of interest from a different sample of participants with the same age range, using resting-state fMRI. In adults, there was greater deactivation of the DMN for scenes that were later remembered than scenes that were later forgotten. In children, deactivation of the default-network did not differ reliably between scenes that were later remembered or forgotten. Adolescents exhibited a pattern of activation intermediate to that of children and adults. The hippocampal region, often considered part of the DMN, showed a functional dissociation with the rest of the DMN by exhibiting increased activation for later remembered than later forgotten scene that was similar across age groups. These findings suggest that development of memory ability from childhood through adulthood may involve increased deactivation of the neocortical DMN during learning.en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.neuroimage.2013.09.032en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleDevelopment of deactivation of the default-mode network during episodic memory formationen_US
dc.typeArticleen_US
dc.identifier.citationChai, Xiaoqian J. et al. “Development of Deactivation of the Default-Mode Network During Episodic Memory Formation.” NeuroImage 84 (January 2014): 932–938 © 2013 Elsevieren_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.mitauthorChai, Xiaoqian
dc.contributor.mitauthorOfen, Noa
dc.contributor.mitauthorGabrieli, John D. E.
dc.contributor.mitauthorWhitfield-Gabrieli, Susan
dc.relation.journalNeuroImageen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsChai, Xiaoqian J.; Ofen, Noa; Gabrieli, John D.E.; Whitfield-Gabrieli, Susanen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-5946-1069
dc.identifier.orcidhttps://orcid.org/0000-0001-5966-2242
dc.identifier.orcidhttps://orcid.org/0000-0003-1158-5692
mit.licensePUBLISHER_CCen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record