Striosome–dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons
Author(s)
Shima, Yasuyuki; Gerfen, Charles R.; Nelson, Sacha B.; Crittenden, Jill R; Tillberg, Paul W.; Riad, Michael; Curry, Jeffrey; Housman, David E; Boyden, Edward; Graybiel, Ann M; ... Show more Show less
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The dopamine systems of the brain powerfully influence movement and motivation. We demonstrate that striatonigral fibers originating in striosomes form highly unusual bouquet-like arborizations that target bundles of ventrally extending dopamine-containing dendrites and clusters of their parent nigral cell bodies. Retrograde tracing showed that these clustered cell bodies in turn project to the striatum as part of the classic nigrostriatal pathway. Thus, these striosome-dendron formations, here termed "striosome-dendron bouquets," likely represent subsystems with the nigro-striato-nigral loop that are affected in human disorders including Parkinson's disease. Within the bouquets, expansion microscopy resolved many individual striosomal fibers tightly intertwined with the dopamine-containing dendrites and also with afferents labeled by glutamatergic, GABAergic, and cholinergic markers and markers for astrocytic cells and fibers and connexin 43 puncta. We suggest that the striosome-dendron bouquets form specialized integrative units within the dopamine-containing nigral system. Given evidence that striosomes receive input from cortical regions related to the control of mood and motivation and that they link functionally to reinforcement and decision-making, the striosome-dendron bouquets could be critical to dopamine-related function in health and disease.
Date issued
2016-09Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Media Laboratory; McGovern Institute for Brain Research at MITJournal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Crittenden, Jill R. et al. “Striosome–dendron Bouquets Highlight a Unique Striatonigral Circuit Targeting Dopamine-Containing Neurons.” Proceedings of the National Academy of Sciences 113, 40 (September 2016): 11318–11323. © 2016 National Academy of Sciences
Version: Author's final manuscript
ISSN
0027-8424
1091-6490