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dc.contributor.authorAkeju, Oluwaseun
dc.contributor.authorHamilos, Allison E.
dc.contributor.authorPavone, Kara J.
dc.contributor.authorSong, Andrew H.
dc.contributor.authorPurdon, Patrick L.
dc.contributor.authorBrown, Emery Neal
dc.date.accessioned2017-11-17T20:43:57Z
dc.date.available2017-11-17T20:43:57Z
dc.date.issued2016-02
dc.identifier.issn1388-2457
dc.identifier.urihttp://hdl.handle.net/1721.1/112231
dc.description.abstractObjective: An emerging paradigm for understanding how anesthetics induce altered arousal is relating receptor targeting in specific neural circuits to electroencephalogram (EEG) activity. Enhanced gamma amino-butyric acid A (GABA[subscript A]) inhibitory post-synaptic currents (IPSCs) manifest with large-amplitude slow (0.1-1 Hz) and frontally coherent alpha (8-12 Hz) EEG oscillations during general anesthesia. Therefore, we investigated the EEG signatures of modern day derivatives of ether (MDDE) anesthesia to assess the extent to which we could obtain insights into MDDE anesthetic mechanisms. Methods: We retrospectively studied cases from our database in which patients received isoflurane anesthesia vs. isoflurane/ketamine anesthesia (n = 10 each) or desflurane anesthesia vs. desflurane/ketamine anesthesia (n = 9 each). We analyzed the EEG recordings with spectral power and coherence methods. Results: Similar to known GABA [subscript A] circuit level mechanisms, we found that MDDE anesthesia induced large amplitude slow and frontally coherent alpha oscillations. Additionally, MDDE anesthesia also induced frontally coherent theta (4-8 Hz) oscillations. Reduction of GABAergic IPSCs with ketamine resulted in beta/gamma (13-40 Hz) oscillations, and significantly reduced MDDE anesthesia-induced slow, theta and alpha oscillation power. Conclusions: Large amplitude slow oscillations and coherent alpha and theta oscillations are moderated by ketamine during MDDE anesthesia. Significance: These observations are consistent with the notion that GABA [subscript A] circuit-level mechanisms are associated with MDDE anesthesia-induced unconsciousness. Keywords: EEG Isoflurane Desflurane Ketamine Slow oscillations Alpha oscillationsen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant DP2-OD006454)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant DP1-OD003646)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant TR01-GM104948)en_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/J.CLINPH.2016.02.012en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleGABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousnessen_US
dc.typeArticleen_US
dc.identifier.citationAkeju, Oluwaseun, et al. “GABAA Circuit Mechanisms Are Associated with Ether Anesthesia-Induced Unconsciousness.” Clinical Neurophysiology 127, 6 (June 2016): 2472–2481 © 2016 International Federation of Clinical Neurophysiologyen_US
dc.contributor.departmentInstitute for Medical Engineering and Scienceen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.mitauthorSong, Andrew H.
dc.contributor.mitauthorPurdon, Patrick L.
dc.contributor.mitauthorBrown, Emery Neal
dc.relation.journalClinical Neurophysiologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2017-11-01T13:24:27Z
dspace.orderedauthorsAkeju, Oluwaseun; Hamilos, Allison E.; Song, Andrew H.; Pavone, Kara J.; Purdon, Patrick L.; Brown, Emery N.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-9356-9156
dc.identifier.orcidhttps://orcid.org/0000-0001-5651-5060
dc.identifier.orcidhttps://orcid.org/0000-0003-2668-7819
mit.licensePUBLISHER_CCen_US


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