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dc.contributor.authorAmaya, Aldo
dc.contributor.authorNguyen, Shannon
dc.contributor.authorLewis, Michael
dc.contributor.authorZhou, Yongdi
dc.contributor.authorZhang, Mingjie
dc.contributor.authorZhou, Yang
dc.contributor.authorKaiser, Tobias
dc.contributor.authorMonteiro, Patricia
dc.contributor.authorZhang, Xiangyu
dc.contributor.authorVan der Goes, Marie-Sophie
dc.contributor.authorWang, Dongqing
dc.contributor.authorBarak, Boaz
dc.contributor.authorZeng, Menglong
dc.contributor.authorLi, Chenchen
dc.contributor.authorLu, Congyi
dc.contributor.authorWells, Michael
dc.contributor.authorSanjana, Neville E
dc.contributor.authorZhang, Feng
dc.contributor.authorFu, Zhanyan
dc.contributor.authorFeng, Guoping
dc.date.accessioned2017-11-21T19:09:20Z
dc.date.available2017-11-21T19:09:20Z
dc.date.issued2015-12
dc.date.submitted2015-08
dc.identifier.issn0896-6273
dc.identifier.issn1097-4199
dc.identifier.urihttp://hdl.handle.net/1721.1/112261
dc.description.abstractGenetic studies have revealed significant overlaps of risk genes among psychiatric disorders. However, it is not clear how different mutations of the same gene contribute to different disorders. We characterized two lines of mutant mice with Shank3 mutations linked to ASD and schizophrenia. We found both shared and distinct synaptic and behavioral phenotypes. Mice with the ASD-linked InsG3680 mutatio n manifest striatal synaptic transmission defects before weaning age and impaired juvenile social interaction, coinciding with the early onset of ASD symptoms. On the other hand, adult mice carrying the schizophrenia-linked R1117X mutation show profound synaptic defects in prefrontal cortex and social dominance behavior. Furthermore, we found differential Shank3 mRNA stability and SHANK1/2 upregulation in these two lines. These data demonstrate that different alleles of the same gene may have distinct phenotypes at molecular, synaptic, and circuit levels in mice, which may inform exploration of these relationships in human patients.en_US
dc.description.sponsorshipNational Institute of Mental Health (U.S.) (Grant 5R01MH097104)en_US
dc.description.sponsorshipNational Institute of Mental Health (U.S.) (Grant 5DP1-MH100706)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01-NS 07312401)en_US
dc.publisherElsevier/Cell Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/J.NEURON.2015.11.023en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleMice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defectsen_US
dc.typeArticleen_US
dc.identifier.citationZhou, Yang, et al. “Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.” Neuron 89, 1 (January 2016): 147–162 © 2016 Elsevier Incen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.mitauthorZhou, Yang
dc.contributor.mitauthorKaiser, Tobias
dc.contributor.mitauthorMonteiro, Patricia
dc.contributor.mitauthorZhang, Xiangyu
dc.contributor.mitauthorVan der Goes, Marie-Sophie
dc.contributor.mitauthorWang, Dongqing
dc.contributor.mitauthorBarak, Boaz
dc.contributor.mitauthorZeng, Menglong
dc.contributor.mitauthorLi, Chenchen
dc.contributor.mitauthorLu, Congyi
dc.contributor.mitauthorWells, Michael
dc.contributor.mitauthorSanjana, Neville E
dc.contributor.mitauthorZhang, Feng
dc.contributor.mitauthorFu, Zhanyan
dc.contributor.mitauthorFeng, Guoping
dc.relation.journalNeuronen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2017-11-03T18:36:06Z
dspace.orderedauthorsZhou, Yang; Kaiser, Tobias; Monteiro, Patrícia; Zhang, Xiangyu; Van der Goes, Marie. S.; Wang, Dongqing; Barak, Boaz; Zeng, Menglong; Li, Chenchen; Lu, Congyi; Wells, Michael; Amaya, Aldo; Nguyen, Shannon; Lewis, Michael; Sanjana, Neville; Zhou, Yongdi; Zhang, Mingjie; Zhang, Feng; Fu, Zhanyan; Feng, Guopingen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-8665-3912
dc.identifier.orcidhttps://orcid.org/0000-0003-3288-4560
dc.identifier.orcidhttps://orcid.org/0000-0001-9658-0342
dc.identifier.orcidhttps://orcid.org/0000-0001-5251-6664
dc.identifier.orcidhttps://orcid.org/0000-0002-4120-4048
dc.identifier.orcidhttps://orcid.org/0000-0002-3546-4740
dc.identifier.orcidhttps://orcid.org/0000-0003-2782-2509
dc.identifier.orcidhttps://orcid.org/0000-0001-9473-2402
dc.identifier.orcidhttps://orcid.org/0000-0002-8021-277X
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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