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Prefrontal Cortex Networks Shift from External to Internal Modes during Learning

Author(s)
Brincat, Scott Louis; Miller, Earl K
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Abstract
As we learn about items in our environment, their neural representations become increasingly enriched with our acquired knowledge. But there is little understanding of how network dynamics and neural processing related to external information changes as it becomes laden with “internal” memories. We sampled spiking and local field potential activity simultaneously from multiple sites in the lateral prefrontal cortex (PFC) and the hippocampus (HPC)—regions critical for sensory associations—of monkeys performing an object paired-associate learning task. We found that in the PFC, evoked potentials to, and neural information about, external sensory stimulation decreased while induced beta-band (~11–27 Hz) oscillatory power and synchrony associated with “top-down” or internal processing increased. By contrast, the HPC showed little evidence of learning-related changes in either spiking activity or network dynamics. The results suggest that during associative learning, PFC networks shift their resources from external to internal processing.
Date issued
2016-08
URI
http://hdl.handle.net/1721.1/112278
Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory
Journal
Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Brincat, S. L. et al. “Prefrontal Cortex Networks Shift from External to Internal Modes During Learning.” Journal of Neuroscience 36, 37 (September 2016): 9739–9754 © 2016 The Author(s)
Version: Final published version
ISSN
0270-6474
1529-2401

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